User profiles for S. Itohara
Shigeyoshi ItoharaRIKEN Verified email at riken.jp Cited by 40865 |
[HTML][HTML] Causal relationship between the loss of RUNX3 expression and gastric cancer
…, H Yamamoto, N Yamashita, T Yano, T Ikeda, S Itohara… - Cell, 2002 - cell.com
… As in the case of hemizygous deletion, silencing by DNA methylation may have affected
gene(s) other than RUNX3. To establish RUNX3 as causally related to gastric carcinogenesis, …
gene(s) other than RUNX3. To establish RUNX3 as causally related to gastric carcinogenesis, …
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
…, T Itoh, K Tamaki, K Tanzawa, P Thorpe, S Itohara… - Nature cell …, 2000 - nature.com
During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates
the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its …
the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its …
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Abstract Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that
TCP-β gene rearrangement or expression is critical for the differentiation of CD4 − CD8 − …
TCP-β gene rearrangement or expression is critical for the differentiation of CD4 − CD8 − …
Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia
S Itohara, AG Farr, JJ Lafaille, M Bonneville… - Nature, 1990 - nature.com
IN mice γδ T-cell populations with distinct T-cell receptor (TCR) repertoires and homing
properties have been identified. Diversified populations are found in lymphoid organs 1–3 and …
properties have been identified. Diversified populations are found in lymphoid organs 1–3 and …
[HTML][HTML] The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis
Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling.
We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates …
We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates …
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
…, M Yamaguchi, K Mori, T Ikeda, S Itohara… - Nature …, 2008 - nature.com
… (q–s) The olfactory bulb of Line 5-1/R26-CFP mice, which received repeated administration
… + granule cells (red) were determined (r,s). Note that CFP labeling of granule cell dendrites …
… + granule cells (red) were determined (r,s). Note that CFP labeling of granule cell dendrites …
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
…, H Yoshida, T Yoshioka, H Nishimoto, S Itohara - Cancer research, 1998 - AACR
Matrix proteolysis is thought to play a crucial role in several stages of tumor progression,
including angiogenesis, and the invasion and metastasis of tumor cells. We investigated the …
including angiogenesis, and the invasion and metastasis of tumor cells. We investigated the …
Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells.
The immunobiology of Trypanosoma cruzi infection in mice is discussed under the following
headings: definition of the immunological problem; the experimental system; the …
headings: definition of the immunological problem; the experimental system; the …
Single App knock-in mouse models of Alzheimer's disease
…, N Mihira, J Takano, P Nilsson, S Itohara… - Nature …, 2014 - nature.com
… s) that may link Aβ amyloidosis and tauopathy. In any case, the advantages lie in the existence
of relevant negative controls and the lack of concern about overexpression artifact(s… (s) …
of relevant negative controls and the lack of concern about overexpression artifact(s… (s) …
Nav1. 1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation
…, E Mazaki, I Inoue, T Takeuchi, S Itohara… - Journal of …, 2007 - Soc Neuroscience
Loss-of-function mutations in human SCN1A gene encoding Na v 1.1 are associated with a
severe epileptic disorder known as severe myoclonic epilepsy in infancy. Here, we …
severe epileptic disorder known as severe myoclonic epilepsy in infancy. Here, we …