Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
…, CT Van Oostrom, RMC Brandt, S Barnhoorn, S Imholz… - Nature, 2016 - nature.com
… 5 s. Whole-body tremor was scored if mice were trembling for a combined total of at least
10 s when put on a flat surface for 20 s. … on a flat surface for 20 s. Mice that had difficulties in …
10 s when put on a flat surface for 20 s. … on a flat surface for 20 s. Mice that had difficulties in …
Worth their weight: An assessment of the evolving field of library evaluation
S Imholz, JW Arns - Public Library Quarterly, 2007 - Taylor & Francis
… Finally, we focus on what’s needed to support the systematic growth and development of …
They have also helped ALC shape this report’s main focus–the relationship between research …
They have also helped ALC shape this report’s main focus–the relationship between research …
[HTML][HTML] Dietary n− 3 and n− 6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the …
Y Lu, EJM Feskens, MET Dollé, S Imholz… - The American journal of …, 2010 - Elsevier
Background: The δ-5 and δ-6 desaturases, encoded by the FADS1 and FADS2 genes, are
rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide …
rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide …
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
…, RMC Brandt, S Barnhoorn, N van Vliet, S Imholz… - Aging …, 2021 - Wiley Online Library
Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple
species. We have recently shown that DR in progeroid DNA repair‐deficient mice dramatically …
species. We have recently shown that DR in progeroid DNA repair‐deficient mice dramatically …
Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study
Y Lu, EJM Feskens, JMA Boer, S Imholz… - Atherosclerosis, 2010 - Elsevier
BACKGROUND: Plasma total cholesterol (TC) levels are highly genetically determined.
Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has …
Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has …
Identification of interleukin‐1 beta, but no other inflammatory proteins, as an early onset pre‐eclampsia biomarker in first trimester serum by bead‐based multiplexed …
…, EJ Wortelboer, MPH Koster, S Imholz… - Prenatal …, 2013 - Wiley Online Library
Objective This study aimed to determine the predictive value of growth factors, cardiovascular,
and immunological markers for first trimester identification of early onset pre‐eclampsia (…
and immunological markers for first trimester identification of early onset pre‐eclampsia (…
Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study
…, S Böhringer, H Putter, S Imholz… - Circulation …, 2012 - Am Heart Assoc
Background— Genome-wide association studies (GWAS) have identified many single-nucleotide
polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk …
polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk …
[HTML][HTML] Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study
…, AHH Merry, MET Dollé, R Hovenier, S Imholz… - PloS one, 2012 - journals.plos.org
… Sequenom’s MassARRAY® Assay Design 3.1 Software was used for SNP assay design,
and Sequenom’s SpectroTyper 4.0 software was used to call genotypes automatically, followed …
and Sequenom’s SpectroTyper 4.0 software was used to call genotypes automatically, followed …
[HTML][HTML] Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrationss⃞
Y Lu, MET Dollé, S Imholz, R van't Slot… - Journal of lipid …, 2008 - ASBMB
The known genetic variants determining plasma HDL cholesterol (HDL-C) levels explain
only part of its variation. Three hundred eighty-four single nucleotide polymorphisms (SNPs) …
only part of its variation. Three hundred eighty-four single nucleotide polymorphisms (SNPs) …
[HTML][HTML] A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction
…, CT van Oostrom, G Ambagtsheer, S Imholz… - Scientific reports, 2017 - nature.com
… Immunoblotting was performed with antibodies directed against S6 (#2217 S Lot5; 1:1.000)
and Phospho-S6 (Ser240/244; #2215 Lot14; 1:500) (Cell Signaling Technology, Danvers, …
and Phospho-S6 (Ser240/244; #2215 Lot14; 1:500) (Cell Signaling Technology, Danvers, …