User profiles for S. Hautaniemi

Sampsa Hautaniemi

Professor of systems biology, Faculty of Medicine, University of Helsinki
Verified email at helsinki.fi
Cited by 12099

Impact of DNA amplification on gene expression patterns in breast cancer

…, P Kauraniemi, S Hautaniemi, M Wolf, S Mousses… - Cancer research, 2002 - AACR
… A database of genomic sequence alignment information for mRNA sequences was
created from the August 2001 freeze of the University of California Santa Cruz’s GoldenPath …

PINA v2. 0: mining interactome modules

…, SM Grimmond, AV Biankin, S Hautaniemi… - Nucleic acids …, 2012 - academic.oup.com
The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource,
which includes a database of unified protein–protein interaction data integrated from six …

Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

A Wolf-Yadlin, S Hautaniemi… - Proceedings of the …, 2007 - National Acad Sciences
Although recent developments in MS have enabled the identification and quantification of
hundreds of phosphorylation sites from a given biological sample, phosphoproteome analysis …

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

…, S Nordling, O Kallioniemi, S Hautaniemi… - The EMBO …, 2011 - embopress.org
High androgen receptor (AR) level in primary tumour predicts increased prostate cancer‐specific
mortality. However, the mechanisms that regulate AR function in prostate cancer are …

[HTML][HTML] Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

…, H Edgren, M Wolf, J Astola, M Nees, S Hautaniemi… - Genome biology, 2008 - Springer
Our knowledge on tissue- and disease-specific functions of human genes is rather limited
and highly context-specific. Here, we have developed a method for the comparison of mRNA …

Integrated network analysis platform for protein-protein interactions

…, K Ovaska, J Westermarck, TP Mäkelä, S Hautaniemi - Nature …, 2009 - nature.com
There is an increasing demand for network analysis of protein-protein interactions (PPIs).
We introduce a web-based protein interaction network analysis platform (PINA), which …

Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer

…, J Hynninen, A Virtanen, A Häkkinen, S Hautaniemi… - Science …, 2022 - science.org
… Funding: This work was supported by the European Union’s Horizon 2020 research and
innovation programme under grant agreement no. 667403 for HERCULES (Comprehensive …

[HTML][HTML] Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

…, S Grénman, R Lehtonen, S Hautaniemi… - Nature …, 2021 - nature.com
Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk,
critically affecting metastasis and treatment resistance, remains elusive. Our results show that …

[HTML][HTML] Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer

…, UA Matulonis, PJ Park, S Hautaniemi… - Nature …, 2020 - nature.com
Combined PARP and immune checkpoint inhibition has yielded encouraging results in
ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling …

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells

…, P Pihlajamaa, K Ovaska, I Sinielnikov, S Hautaniemi… - Cancer research, 2013 - AACR
… Further studies are needed to elucidate the mechanism(s) by which the partial antiandrogenic
action of Dex is elicited; intriguingly, it does not appear to involve direct competition …