The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC)
investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets …

Adipose tissue is an enormously active endocrine organ, secreting various hormones, such
as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor …

Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal …

Abstract Characterization of the prostate cancer transcriptome and genome has identified
chromosomal rearrangements and copy number gains and losses, including ETS gene family …

Prostate cancer is a leading cause of cancer-related death in males and is second only to
lung cancer. Although effective surgical and radiation treatments exist for clinically localized …

Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology
and disease processes including cancer. To delineate genome-wide lncRNA expression, …

Prostate cancer is the most frequently diagnosed cancer in American men 1 , 2 . Screening
for prostate-specific antigen (PSA) has led to earlier detection of prostate cancer 3 , but …

Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes …

Despite efforts to profile prostate cancer, the genetic alterations and biological processes
that correlate with the observed histological progression are unclear. Using laser-capture …

Circular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed structure,
high stability, and implicated roles in gene regulation. Here, we used an exome capture …