To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor …

ContextThe selection of individuals for hereditary nonpolyposis colorectal cancer (HNPCC)
genetic testing is challenging. Recently, the National Cancer Institute outlined a new set of …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide
association study meta-analysis of 100,204 CRC cases and 154,587 controls of …

Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises …

Colorectal cancer (CRC) has one of the most familial components of all human cancers.
However, only a small fraction—up to 3%–5%—arise in the setting of the highly penetrant …

… active is associated with less weight gain and body fatness, and lower adiposity is associated
with lower risks of breast and colorectal cancer 15,16 . Since body size/adiposity is likely …

… The molecular signature of LS is microsatellite instability (MSI), which is found in more than
95% of LS-associated CRCs. However, MSI is also present in up to 15% of sporadic CRCs …

… As it is likely that thousands of genetic variants contribute to CRC risk, it is clinically important
to investigate whether these genetic variants can be used jointly for CRC risk prediction. In …

… gene is not found, the cause of MMR deficiency is unknown but probably it is not sporadic.
Another group of cancers where the cause of MMR gene silencing is unclear is when there is …