User profiles for S. Boland

Sebastian Boland

Prevail Therapeutics
Verified email at hsph.harvard.edu
Cited by 1187

Nanoparticles: molecular targets and cell signalling

…, F Rodrigues-Lima, A Baeza-Squiban, S Boland - Archives of …, 2011 - Springer
Increasing evidence linking nanoparticles (NPs) with different cellular outcomes necessitate
an urgent need for the better understanding of cellular signalling pathways triggered by NPs…

Record-setting algal bloom in Lake Erie caused by agricultural and meteorological trends consistent with expected future conditions

…, EJ Anderson, D Beletsky, S Boland… - Proceedings of the …, 2013 - National Acad Sciences
In 2011, Lake Erie experienced the largest harmful algal bloom in its recorded history, with a
peak intensity over three times greater than any previously observed bloom. Here we show …

Towards an alternative testing strategy for nanomaterials used in nanomedicine: lessons from NanoTEST

M Dusinska, S Boland, M Saunders… - …, 2015 - Taylor & Francis
In spite of recent advances in describing the health outcomes of exposure to nanoparticles (NPs),
it still remains unclear how exactly NPs interact with their cellular targets. Size, surface, …

Rho kinase inhibitors: a patent review (2014–2016)

O Defert, S Boland - Expert opinion on therapeutic patents, 2017 - Taylor & Francis
… O Defert is an independent manager and S Boland is a former employee of Amakem
Therapeutics NV. The authors have no other relevant affiliations or financial involvement with any …

Structure of perceptions of older adults: evidence for multiple stereotypes.

DF Schmidt, SM Boland - Psychology and aging, 1986 - psycnet.apa.org
We examined the possibility that people hold multiple stereotypes of the elderly. Subjects
were male and female university students. In the first phase of our study, stereotype content …

Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles: role of particle surface area and internalized amount

S Hussain, S Boland, A Baeza-Squiban, R Hamel… - Toxicology, 2009 - Elsevier
… Immediately prior to use NPs were sonicated three times for 20 s at 60 W. NPs were utilized
over a range of doses from 5 to 160 μg cm −2 (24–760 μg mL −1 ). Working suspensions …

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

…, P Narayan, JM Bonner, N Kory, S Boland… - Science translational …, 2021 - science.org
… Our study suggests that APOE4’s status as a genetic risk factor for AD and other distinct
diseases originates from the pleiotropic consequences of perturbed lipid metabolism …

Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1A1 expression

…, A Baulig, S Brulant, S Boland… - American journal of …, 2001 - atsjournals.org
… Nuclei were spun down at 16,000 × g for 30 s after the addition of a 10% Nonidet P-40
solution, then resuspended in 40 μl of a hyperosmotic buffer (50 mM Hepes, 50 mM KCl, 300 mM …

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

…, C Liu, K Donckers, A Stoycheva, S Boland… - MBio, 2023 - Am Soc Microbiol
… The oxygen atom of the inhibitor’s warhead interacts with the backbone NH of C145 in the
oxyanion hole. The carbonyl oxygen of the P1 lactam hydrogen-bonds to the side chain of …

[HTML][HTML] Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells

…, A Baeza-Squiban, F Marano, S Boland - Particle and fibre …, 2010 - Springer
… NPs were sonicated three times for 20 s at 60 W within 5 minutes prior to dilution in cell
culture media. For most of the experiments NP exposure was done at 20 μg.cm -2 corresponding …