Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA-…

The objective of this paper is to critically review the literature regarding the mechanics,
geometry, load application and other testing parameters of “micro” shear and tensile adhesion …

From its beginnings two decades ago with the analysis of chromosomal translocation
breakpoints, research into the molecular pathogenesis of acute lymphoblastic leukemia (ALL) has …

Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-lineage
leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show …

To pursue a systematic approach to the discovery of functional connections among diseases,
genetic perturbation, and drug action, we have created the first installment of a reference …

To understand the role of FoxO family members in hematopoiesis, we conditionally deleted
FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited …

The current and long-term health of 14.4 million children and adolescents is affected by obesity,
1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long stigmatized …

… an audit of Douglas’s tax returns only five days after the President’s inauguration. At the
same time, the FBI was compiling information on Douglas’s connections with Las Vegas casino …

Leukaemias and other cancers possess a rare population of cells capable of the limitless
self-renewal necessary for cancer initiation and maintenance 1 , 2 , 3 , 4 , 5 , 6 , 7 . Eradication …

OBJECTIVES: To provide updated prevalence data on obesity trends among US children
and adolescents aged 2 to 19 years from a nationally representative sample. METHODS: We …