Quality control guidelines for clinical-grade human induced pluripotent stem cell lines
…, H Stachelscheid, SR Velayudhan… - Regenerative …, 2018 - Future Medicine
Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material
for the generation of cellular therapeutics requires demonstration of comparability of lines …
for the generation of cellular therapeutics requires demonstration of comparability of lines …
[HTML][HTML] Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2
…, P Krishnamurthy, V Mathews, SR Velayudhan… - PloS one, 2017 - journals.plos.org
… SV is a recipient of a senior research fellowship from Indian Council of Medical Research.
VM and PB are supported by Senior Fellowship from Wellcome DBT India Alliance (IA/S/11/…
VM and PB are supported by Senior Fellowship from Wellcome DBT India Alliance (IA/S/11/…
Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin
…, S Thangavel, S Marepally, SR Velayudhan… - Elife, 2022 - elifesciences.org
Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from
defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary …
defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary …
[HTML][HTML] Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo
Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs),
remain unexplored in hematological malignancies except for retinoic acid receptor alpha (…
remain unexplored in hematological malignancies except for retinoic acid receptor alpha (…
Systematic evaluation of markers used for the identification of human induced pluripotent stem cells
…, MD Pratheesh, A Srivastava, SR Velayudhan - Biology …, 2017 - journals.biologists.com
Low efficiency of somatic cell reprogramming and heterogeneity among human induced
pluripotent stem cells (hiPSCs) demand extensive characterization of isolated clones before …
pluripotent stem cells (hiPSCs) demand extensive characterization of isolated clones before …
[HTML][HTML] Direct generation of immortalized erythroid progenitor cell lines from peripheral blood mononuclear cells
…, KM Mohankumar, S Thangavel, SR Velayudhan - Cells, 2021 - mdpi.com
Reliable human erythroid progenitor cell (EPC) lines that can differentiate to the later stages
of erythropoiesis are important cellular models for studying molecular mechanisms of …
of erythropoiesis are important cellular models for studying molecular mechanisms of …
Long-term outcome of mixed chimerism after stem cell transplantation for thalassemia major conditioned with busulfan and cyclophosphamide
…, KM Lakshmi, A Korula, SR Velayudhan… - Bone Marrow …, 2018 - nature.com
Mixed chimerism (MC) occurs frequently after allogeneic hematopoietic stem cell transplantation
(HSCT) for thalassemia major (TM) and may be associated with rejection. We report the …
(HSCT) for thalassemia major (TM) and may be associated with rejection. We report the …
[HTML][HTML] Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies
…, KM Mohankumar, SR Velayudhan… - … Therapy-Nucleic Acids, 2023 - cell.com
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies.
However, the continued production of defective adult hemoglobin (HbA) …
However, the continued production of defective adult hemoglobin (HbA) …
Chemotherapeutic drugs elicit stemness and metabolic alteration to mediate acquired drug-resistant phenotype in acute myeloid leukemia cell lines
Chemotherapy resistance leading to disease relapse is a significant barrier in treating acute
myeloid leukemia (AML). Metabolic adaptations have been shown to contribute to therapy …
myeloid leukemia (AML). Metabolic adaptations have been shown to contribute to therapy …
[HTML][HTML] Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression
…, E David, M Murugesan, SR Velayudhan - Scientific Reports, 2023 - nature.com
The preferred method for disease modeling using induced pluripotent stem cells (iPSCs) is
to generate isogenic cell lines by correcting or introducing pathogenic mutations. Base …
to generate isogenic cell lines by correcting or introducing pathogenic mutations. Base …