Recent experiments have revealed surprising behavior in the yeast galactose (GAL) pathway,
one of the preeminent systems for studying gene regulation. Under certain circumstances, …

Human cancers often contain genetic alterations that disable G1/S checkpoint control and
loss of this checkpoint is thought to critically contribute to cancer generation by permitting …

The essential mitotic kinase Aurora A (AURKA) is controlled during cell cycle progression
via two distinct mechanisms. Following activation loop autophosphorylation early in mitosis …

Deregulation of cyclin-dependent kinases 4 and 6 (CDK4/6) is highly prevalent in cancer;
yet, inhibitors against these kinases are currently used only in restricted tumour contexts. The …

Organisms must carefully control their metabolism in order to survive. On the other hand,
enzymes must adapt in response to evolutionary pressures on the pathways in which they are …

Examined the effect (s) of counselor touch on client evaluation of counseling and level of self-exploration.
25 counselors and 100 undergraduates participated. Nonverbal condition (…

DNA damage activates checkpoint controls which block progression of cells through the
division cycle. Several different checkpoints exist that control transit at different positions in the …

When a cell encounters a new environment, its transcriptional response can be constrained
by its history. For example, yeast cells in galactose induce GAL genes with a speed and …

Advances in understanding the control mechanisms governing the behavior of cells in
adherent mammalian tissue culture models are becoming increasingly dependent on modes of …

… of strontium on the degree of silicon modification in the 319 aluminium alloy, and (ii) to determine
the effects of strontium … This investigation showed that a strontium level between 75 and …