Transcriptional changes occur presymptomatically and throughout Huntington's disease (
HD ), motivating the study of transcriptional regulatory networks ( TRN s) in HD . We …

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …

Objective To evaluate the contemporary trends in outcomes and resource use associated with
transcatheter aortic valve replacement (TAVR) in the United States. Methods We identified …

We investigated the appearance and progression of disease-relevant signs in the B6.Htt
Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (…

Huntington’s disease arises from a toxic gain of function in the huntingtin (HTT) gene. As a
result, many HTT-lowering therapies are being pursued in clinical studies, including those …

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease whose
predominant neuropathological signature is the selective loss of medium spiny neurons in the …

The effect of a constant magnetic field, applied at an angle ψ to the easy axis of magnetization,
on the Néel relaxation time τ of a single domain ferromagnetic particle (with uniaxial …

Apathy is one of the most prevalent and progressive psychiatric symptoms in Huntington’s
disease (HD) patients. However, preclinical work in HD mouse models tends to focus on …

Expanded trinucleotide repeats cause many human diseases, including Huntington’s
disease (HD). Recent studies indicate that somatic instability of these repeats contributes to …

Progressive striatal gene expression changes and epigenetic alterations are a prominent
feature of Huntington’s disease (HD), but direct relationships between the huntingtin (HTT) …