User profiles for S. R. Brant
 | Steven R BrantProfessor of Medicine, Rutgers University and Johns Hopkins University Verified email at rwjms.rutgers.edu Cited by 48338 |
Recent insights into the genetics of inflammatory bowel disease
JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …
Mammalian Na+/H+ exchanger gene family: structure and function studies
Na+/H+ exchangers are integral plasma membrane proteins that exchange extracellular Na+
for intracellular H+ with a stoichiometry of one for one. They are inhibitable by the diuretic …
for intracellular H+ with a stoichiometry of one for one. They are inhibitable by the diuretic …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress …
…, IDR Arnott, CN Bernstein, SR Brant… - Canadian Journal of …, 2005 - hindawi.com
The discovery of a series of genetic and serological markers associated with disease
susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an …
susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …
studies. To advance gene discovery further, we combined data from three studies on …
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is
thought to result from the effect of environmental factors in a genetically predisposed host. A …
thought to result from the effect of environmental factors in a genetically predisposed host. A …
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease. …
replication studies that identify several new regions of association to Crohn disease. …
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic
disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify …
disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…