User profiles for S. P. Pearce

Stephen Pearce

- Verified email at rothamsted.ac.uk - Cited by 2688

Simon P. Pearce

- Verified email at manchester.ac.uk - Cited by 1957

[PDF][PDF] Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors

…, JV Conde, CS Correia, SP Pearce… - Molecular Cell, 2014 - cell.com
Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants,
NO regulates critical developmental transitions and stress responses. Here, we identify a …

[HTML][HTML] cfDNA methylome profiling for detection and subtyping of small cell lung cancers

F Chemi, SP Pearce, A Clipson, SM Hill, AM Conway… - Nature cancer, 2022 - nature.com
Small cell lung cancer (SCLC) is characterized by morphologic, epigenetic and transcriptomic
heterogeneity. Subtypes based upon predominant transcription factor expression have …

Regulation of Freezing Tolerance and Flowering in Temperate Cereals: The VRN-1 Connection

T Dhillon, SP Pearce, EJ Stockinger… - Plant …, 2010 - academic.oup.com
In winter wheat (Triticum spp.) and barley (Hordeum vulgare) varieties, long exposures to
nonfreezing cold temperatures accelerate flowering time (vernalization) and improve freezing …

Systems Analysis of Auxin Transport in the Arabidopsis Root Apex

…, L Yu, W Li, HI Hijazi, J Oh, SP Pearce… - The Plant …, 2014 - academic.oup.com
Auxin is a key regulator of plant growth and development. Within the root tip, auxin distribution
plays a crucial role specifying developmental zones and coordinating tropic responses. …

A biobank of small cell lung cancer CDX models elucidates inter-and intratumoral phenotypic heterogeneity

…, R Stoney, KK Frese, N Simms, W Rowe, SP Pearce… - Nature Cancer, 2020 - nature.com
Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and
preclinical models reveal heterogeneity in transcriptomes and morphology. SCLC subtypes …

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

…, N McGranahan, S Gulati, C Abbosh, SP Pearce… - Nature medicine, 2019 - nature.com
Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who
undergo surgery with curative intent will relapse within 5 years 1 , 2 . Detection of circulating …

[HTML][HTML] A conceptual view at microtubule plus end dynamics in neuronal axons

A Voelzmann, I Hahn, SP Pearce… - Brain research …, 2016 - Elsevier
Axons are the cable-like protrusions of neurons which wire up the nervous system. Polar
bundles of microtubules (MTs) constitute their structural backbones and are highways for life-…

Post-bifurcation analysis of a thin-walled hyperelastic tube under inflation

YB Fu, SP Pearce, KK Liu - International Journal of Non-Linear Mechanics, 2008 - Elsevier
We consider the problem of bulging, or necking, of an infinite thin-walled hyperelastic tube
that is inflated by an internal pressure, with the axial stretch at infinity maintained at unity. We …

Periodic actin structures in neuronal axons are required to maintain microtubules

Y Qu, I Hahn, SED Webb, SP Pearce… - Molecular biology of the …, 2017 - Am Soc Cell Biol
Axons are cable-like neuronal processes wiring the nervous system. They contain parallel
bundles of microtubules as structural backbones, surrounded by regularly spaced actin rings …

[HTML][HTML] Effect of the down-regulation of the high Grain Protein Content (GPC) genes on the wheat transcriptome during monocarpic senescence

D Cantu, SP Pearce, A Distelfeld, MW Christiansen… - BMC genomics, 2011 - Springer
Background Increasing the nutrient concentration of wheat grains is important to ameliorate
nutritional deficiencies in many parts of the world. Proteins and nutrients in the wheat grain …