Background The incidence of acute coronary-artery occlusion among patients with sudden
cardiac arrest outside of the hospital is unknown, and the role of reperfusion therapy has not …

Genetic tests can help clinicians to diagnose rare monogenic liver diseases. For most common
liver diseases, however, multiple gene variants that have small to moderate individual …

To elucidate the pathogenesis of bronchospasm in congestive heart failure, we studied 23
patients with chronic impairment of left ventricular function due to coronary artery disease or …

Attempting to achieve the high diversity of training goals in modern competitive alpine skiing
simultaneously can be difficult and may lead to compromised overall adaptation. Therefore, …

Aims Inflammation plays an important role in cardiovascular disease (CVD) development.
The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of …

The influence of size differences, shape, mass, and persistent motion on phase separation
in binary mixtures has been intensively studied. Here we focus on the exclusive role of …

An important feature of the cerebral cortex is its layered organization, which is modulated in
an area-specific manner. We found that the transcription factor AP2γ regulates laminar fate …

Background Liver cirrhosis is a major cause of death worldwide. Cirrhosis develops after a
long asymptomatic period of fibrosis progression, with the diagnosis frequently occurring late, …

Better understanding of the pathomechanisms of gallstone disease might help to overcome
the current invasive treatment of this exceptionally prevalent and economically significant …

TGF-β1 is a major player in chronic liver diseases promoting fibrogenesis and tumorigenesis
through various mechanisms. The expression and function of TGF-β2 have not been …