More than 110,000 tracheostomies are placed annually in the United States. 1 The overall
complication incidence is 40% to 50%. Thankfully, the vast majority of these complications are …

Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal
instability (CIN) remains unclear for many tumor types. Here, we identify CIN initiation as a …

Intratumoral phenotypic heterogeneity has been described in many tumor types, where it
can contribute to drug resistance and disease recurrence. We analyzed ductal and …

Background— Activated protein C resistance due to factor V Leiden (FVL) is a common
genetic risk factor for venous thrombosis in humans. Although the impact of FVL on the …

Background Physical activity is associated with a lower risk of disease recurrence among
colon cancer patients. Circulating tumor cells (CTC) are prognostic of disease recurrence …

Background— Factor V Leiden (FVL) is a common genetic risk factor for thrombosis in humans.
The incomplete penetrance of FVL suggests important contributions from other genetic or …

<p>Conventional genetically engineered mouse models (GEMM) are time-consuming,
laborious, and offer limited spatiotemporal control. Here, we describe the development of a …

Oncology research is increasingly incorporating molecular detection of circulating tumor
DNA (ctDNA) as a tool for cancer surveillance and early detection. However, noninvasive …

In characterizing mice with targeted disruption of the SerpinB2 gene, we observed animals
that were small at birth with delayed growth and decreased life expectancy. Although this …

Results Four studies with a total of 288 patients were analyzed; 3 studies compared albumin
with no albumin, whereas 1 study used artificial colloid as the control. I2 and Cochrane Q …