In 1997, while still working at NeXstar Pharmaceuticals, several of us made a proteomic bet.
We thought then, and continue to think, that proteomics offers a chance to identify disease-…

Aptamers and the SELEX process were discovered over two decades ago. These discoveries
have spawned a productive academic and commercial industry. The collective results …

Although plasma proteins have important roles in biological processes and are the direct
targets of many drugs, the genetic factors that control inter-individual variation in plasma …

Progression from health to disease is accompanied by complex changes in protein expression
in both the circulation and affected tissues. Large-scale comparative interrogation of the …

… Wilcox, unpublished results). TNFRSF9 is a member of the TNF receptor super family and
contributes to the clonal expansion, survival, and development of human T cells. It has a pI of …

Recently, we reported a SOMAmer-based, highly multiplexed assay for the purpose of
biomarker identification. To enable seamless transition from highly multiplexed biomarker …

Multiplexed photoaptamer‐based arrays that allow for the simultaneous measurement of
multiple proteins of interest in serum samples are described. Since photoaptamers covalently …

R‐spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth
factors. Various membrane proteins have been proposed as potential receptors of R‐spondin, …

Commonly, preservice elementary teachers bring to their professional studies deeply rooted
ideas about teaching and learning mathematics. These ideas are embedded in the content …

Lung cancer remains the most common cause of cancer-related mortality. We applied a highly
multiplexed proteomic technology (SOMAscan) to compare protein expression signatures …