Growing evidence shows that epigenetic mechanisms contribute to complex traits, with
implications across many fields of biology. In plant ecology, recent studies have attempted to …

Background Orthology analysis is an important part of data analysis in many areas of
bioinformatics such as comparative genomics and molecular phylogenetics. The ever-increasing …

The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of
lobe-finned fish was thought to have become extinct 70 million years ago. The modern …

Scientific theories seek to provide simple explanations for significant empirical regularities
based on fundamental physical and mechanistic constraints. Biological theories have rarely …

Motivation Sequence-based methods for phylogenetic reconstruction from (nucleic acid)
sequence data are notoriously plagued by two effects: homoplasies and alignment errors. …

Vault RNAs (vtRNAs) are small, about 100 nt long, polymerase III transcripts contained in
the vault particles of eukaryotic cells. Presumably due to their enigmatic function, they have …

Starting with the discovery of microRNAs and the advent of genome‐wide transcriptomics,
non‐protein‐coding transcripts have moved from a fringe topic to a central field research in …

The elucidation of orthology relationships is an important step both in gene function prediction
as well as towards understanding patterns of sequence evolution. Orthology assignments …

The cell cycle genes homology region (CHR) has been identified as a DNA element with an
important role in transcriptional regulation of late cell cycle genes. It has been shown that …

Background Surprisingly little is known about the organization and distribution of tRNA genes
and tRNA-related sequences on a genome-wide scale. While tRNA gene complements …