The current crop of antibiotics in clinical use are either natural products or their derivatives.
However, the rise of a multitude of different antibiotic resistant human pathogens has meant …

Covering: up to January 2008 Mycolactones are a family of highly related macrocyclic
polyketides that exhibit immunosuppressive and cytotoxic properties. First discovered in 1999, …

Covering: up to September 2012.A total of 211 complete and published genomes from
anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene …

Alcohol-based disinfectants and particularly hand rubs are a key way to control hospital
infections worldwide. Such disinfectants restrict transmission of pathogens, such as multidrug-…

Background Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a destructive
skin disease found predominantly in sub-Saharan Africa and south-eastern Australia. The …

Xenorhabdus and Photorhabdus species dedicate a large amount of resources to the
production of specialized metabolites derived from non-ribosomal peptide synthetase (NRPS) or …

Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other
organisms through natural products. Xenorhabdus and Photorhabdus (XP) living in …

Background Ribosomally synthesized and post-translationally modified peptides (RiPPs)
are a diverse group of biologically active bacterial molecules. Due to the conserved genomic …

Addressing the transmission enigma of the neglected disease Buruli ulcer (BU) is a World
Health Organization priority. In Australia, we have observed an association between …

Background Reef-building corals are acutely threatened by ocean warming, calling for active
interventions to reduce coral bleaching and mortality. Corals associate with a wide diversity …