DNA sequence information underpins genetic research, enabling discoveries of important
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …

For 10,000 years pigs and humans have shared a close and complex relationship. From
domestication to modern breeding practices, humans have shaped the genomes of domestic …

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development, …

Legumes (Fabaceae or Leguminosae) are unique among cultivated plants for their ability to
carry out endosymbiotic nitrogen fixation with rhizobial bacteria, a process that takes place …

Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human
genome. The finished sequence comprises 166,880,988 base pairs, representing the largest …

The International Human Genome Sequencing Consortium (IHGSC) used a hierarchical
mapping and sequencing strategy to construct the working draft of the human genome. This …

Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation. …

Improvement of variant calling in next-generation sequence data requires a comprehensive,
genome-wide catalog of high-confidence variants called in a set of genomes for use as a …

Genome sequencing of the model legumes, Medicago truncatula and Lotus japonicus, provides
an opportunity for large-scale sequence-based comparison of two genomes in the same …

Identifying large expansions of short tandem repeats (STRs), such as those that cause
amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-…