User profiles for S. J. Bouley
Stephanie Joy BouleyMassachusetts General Hospital Verified email at mgh.harvard.edu Cited by 145 |
[HTML][HTML] Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma …
…, TA Colacchio, M Wood, BZ Kacsoh, SJ Bouley… - Oncotarget, 2016 - ncbi.nlm.nih.gov
N-of-1 trials target actionable mutations, yet such approaches do not test genomically-informed
therapies in patient tumor models prior to patient treatment. To address this, we …
therapies in patient tumor models prior to patient treatment. To address this, we …
PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing
DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the
function of DICER1 in miRNA processing. Studying the molecular, cellular and oncogenic …
function of DICER1 in miRNA processing. Studying the molecular, cellular and oncogenic …
[HTML][HTML] A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma
Background We have identified molecules that exhibit synthetic lethality in cells with loss of
the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have …
the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have …
Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast …
SR Hosford, LM Dillon, SJ Bouley, R Rosati… - Clinical Cancer …, 2017 - AACR
Purpose: Determine the roles of the PI3K isoforms p110α and p110β in PTEN-deficient,
estrogen receptor α (ER)-positive breast cancer, and the therapeutic potential of isoform-…
estrogen receptor α (ER)-positive breast cancer, and the therapeutic potential of isoform-…
[HTML][HTML] Host cell autophagy promotes BK virus infection
SJ Bouley, MS Maginnis, A Derdowski, GV Gee… - Virology, 2014 - Elsevier
Autophagy is important for a variety for virus life cycles. We sought to determine the role of
autophagy in human BK polyomavirus (BKPyV) infection. The addition excess amino acids …
autophagy in human BK polyomavirus (BKPyV) infection. The addition excess amino acids …
[HTML][HTML] Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells
RJ Allaway, MD Wood, SL Downey, SJ Bouley… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Neurofibromatosis type 1 is a disease caused by mutation of neurofibromin 1 (NF1), loss of
which results in hyperactive Ras signaling and a concomitant increase in cell proliferation …
which results in hyperactive Ras signaling and a concomitant increase in cell proliferation …
Synthetic lethal screening identifies existing drugs with selective viability effects on Neurofibromatosis type-1 model systems
Neurofibromatosis type 1 (NF1) is a genetic disorder associated with various symptoms
including the formation of benign tumors along nerves. Drug treatments are currently limited. The …
including the formation of benign tumors along nerves. Drug treatments are currently limited. The …
Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers
…, WJA Meuling, W Van Dokkum, C Bouley - European journal of …, 1998 - nature.com
Objective: To investigate in adult male volunteers the effect of a new fermented milk product,
fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood …
fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood …
The mouse polyubiquitin gene UbC is essential for fetal liver development, cell‐cycle progression and stress tolerance
…, R Maehr, CA Gilchrist, MA Long, DM Bouley… - The EMBO …, 2007 - embopress.org
UbC is one of two stress‐inducible polyubiquitin genes in mammals and is thought to
supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during …
supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during …
[HTML][HTML] Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype
…, KD Montgomery, I Espinosa, DM Bouley… - British journal of …, 2010 - nature.com
Background: Tumours contain hypoxic regions that select for an aggressive cell phenotype;
tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with …
tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with …