N-of-1 trials target actionable mutations, yet such approaches do not test genomically-informed
therapies in patient tumor models prior to patient treatment. To address this, we …

DICER1 syndrome is a cancer pre-disposition disorder caused by mutations that disrupt the
function of DICER1 in miRNA processing. Studying the molecular, cellular and oncogenic …

Background We have identified molecules that exhibit synthetic lethality in cells with loss of
the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have …

Purpose: Determine the roles of the PI3K isoforms p110α and p110β in PTEN-deficient,
estrogen receptor α (ER)-positive breast cancer, and the therapeutic potential of isoform-…

Autophagy is important for a variety for virus life cycles. We sought to determine the role of
autophagy in human BK polyomavirus (BKPyV) infection. The addition excess amino acids …

Neurofibromatosis type 1 is a disease caused by mutation of neurofibromin 1 (NF1), loss of
which results in hyperactive Ras signaling and a concomitant increase in cell proliferation …

Neurofibromatosis type 1 (NF1) is a genetic disorder associated with various symptoms
including the formation of benign tumors along nerves. Drug treatments are currently limited. The …

Objective: To investigate in adult male volunteers the effect of a new fermented milk product,
fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood …

UbC is one of two stress‐inducible polyubiquitin genes in mammals and is thought to
supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during …

Background: Tumours contain hypoxic regions that select for an aggressive cell phenotype;
tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with …