Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

…, JS Duncan, MC Whittle, SP Angus, SH Velarde… - Cancer discovery, 2017 - AACR
Targeting the dysregulated BRAF–MEK–ERK pathway in cancer has increasingly emerged
in clinical trial design. Despite clinical responses in specific cancers using inhibitors …

[HTML][HTML] Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer

…, DR Goulet, SM Bevill, SP Angus, SH Velarde… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Multiplexed small molecule inhibitors covalently bound to Sepharose beads (MIBs) were
used to capture functional kinases in luminal, HER2-enriched and triple negative (basal-like …

Drops, liquid layers and the Marangoni effect

MG Velarde - … Transactions of the Royal Society of …, 1998 - royalsocietypublishing.org
An overview is given of recent results about the onset and development of steady and time–dependent
flow motions past an instability threshold induced by the Marangoni effect. First, I …

Abstract A30: Kinome dynamics in triple negative breast cancer in response to chemotherapy

SH Velarde, J Usary, C Perou, GL Johnson - Clinical Cancer Research, 2017 - AACR
Triple negative breast cancers (TNBC) have lower expression levels of the receptors (estrogen,
progesterone, Her2) used in targeted therapy than other breast cancer subtypes. This …

Abstract B24: Triple-negative breast cancer adaptive response to MEK inhibition is regulated by the induction of super-enhancers

…, TJ Stuhlmiller, D Singh, N Sciaky, SH Velarde… - Molecular Cancer …, 2016 - AACR
A predominant mechanism by which cancer cells circumvent the action of targeted kinase
inhibitors is the activation of bypass signaling networks that reactivate cellular proliferation. In …

Evidence for interhemispheric mercury exchange in the Pacific Ocean upper troposphere

…, M Andrade, I Moreno, F Velarde… - Journal of …, 2022 - Wiley Online Library
… mercury difference to large emissions from SH oceans or to the exchange of airborne …
We examine and exclude potential SH sources for this increase, such as mercury emissions …

Pablita Velarde

S Hyer - Art Journal, 1994 - search.proquest.com
Velarde struggled to establish herself as an artist in the 1940s and … Velarde was not only the
first Pueblo woman to pursue a … SH: How has age affected the content of your work? PV: The …

[HTML][HTML] Seasonality of the particle number concentration and size distribution: a global analysis retrieved from the network of Global Atmosphere Watch (GAW) near …

…, V Vakkari, PG Van Zyl, F Velarde… - Atmospheric …, 2021 - acp.copernicus.org
Aerosol particles are a complex component of the atmospheric system that influences climate
directly by interacting with solar radiation, and indirectly by contributing to cloud formation. …

[HTML][HTML] In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy

…, HF Tu, C Huang, B Lee, E Velarde… - The Journal of …, 2024 - Am Soc Clin Investig
Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain
unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs …

Consistency in the sum frequency generation intensity and phase vibrational spectra of the air/neat water interface

R Feng, Y Guo, R Lü, L Velarde… - The Journal of Physical …, 2011 - ACS Publications
SH signal on the reference crystal, and this SH signal then interferes with the SH signal
generated from the liquid surface. Because this interference occurs only when these two SH