User profiles for S. E. Schumacher
Steven SchumacherBroad Institute Verified email at broadinstitute.org Cited by 90028 |
[HTML][HTML] GISTIC2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
We describe methods with enhanced power and specificity to identify genes targeted by
somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA …
somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA …
[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
[HTML][HTML] Pan-cancer patterns of somatic copy number alteration
Determining how somatic copy number alterations (SCNAs) promote cancer is an important
goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas Pan…
goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas Pan…
[PDF][PDF] Comprehensive molecular portraits of invasive lobular breast cancer
…, CM Perou, T Pihl, G Saksena, SE Schumacher… - Cell, 2015 - cell.com
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …
[PDF][PDF] Comprehensive and integrative genomic characterization of hepatocellular carcinoma
Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …
[PDF][PDF] Machine learning identifies stemness features associated with oncogenic dedifferentiation
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
[PDF][PDF] Integrated genomic characterization of pancreatic ductal adenocarcinoma
…, R Beroukhim, G Saksena, SE Schumacher… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …
[HTML][HTML] Sequence analysis of mutations and translocations across breast cancer subtypes
…, SL Romero-Cordoba, SE Schumacher… - Nature, 2012 - nature.com
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone 1 . This malignancy …
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone 1 . This malignancy …
[PDF][PDF] Integrative analysis identifies four molecular and clinical subsets in uveal melanoma
…, JE Schein, L Schoenfield, SE Schumacher… - Cancer cell, 2017 - cell.com
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly
distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3…
distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3…