User profiles for S. E. Schumacher

Steven Schumacher

Broad Institute
Verified email at broadinstitute.org
Cited by 90028

[HTML][HTML] GISTIC2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

CH Mermel, SE Schumacher, B Hill, ML Meyerson… - Genome biology, 2011 - Springer
We describe methods with enhanced power and specificity to identify genes targeted by
somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA …

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, GF Gao, G Ha, M Meyerson, SE Schumacher… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer

…, GF Gao, G Ha, M Meyerson, SE Schumacher… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

[HTML][HTML] Pan-cancer patterns of somatic copy number alteration

TI Zack, SE Schumacher, SL Carter, AD Cherniack… - Nature …, 2013 - nature.com
Determining how somatic copy number alterations (SCNAs) promote cancer is an important
goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas Pan…

[PDF][PDF] Comprehensive molecular portraits of invasive lobular breast cancer

…, CM Perou, T Pihl, G Saksena, SE Schumacher… - Cell, 2015 - cell.com
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …

[PDF][PDF] Comprehensive and integrative genomic characterization of hepatocellular carcinoma

…, J Shih, R Beroukhim, AD Cherniack, SE Schumacher… - Cell, 2017 - cell.com
Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

[PDF][PDF] Machine learning identifies stemness features associated with oncogenic dedifferentiation

…, GF Gao, G Ha, M Meyerson, SE Schumacher - Cell, 2018 - cell.com
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …

[PDF][PDF] Integrated genomic characterization of pancreatic ductal adenocarcinoma

…, R Beroukhim, G Saksena, SE Schumacher… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

[HTML][HTML] Sequence analysis of mutations and translocations across breast cancer subtypes

…, SL Romero-Cordoba, SE Schumacher… - Nature, 2012 - nature.com
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone 1 . This malignancy …

[PDF][PDF] Integrative analysis identifies four molecular and clinical subsets in uveal melanoma

…, JE Schein, L Schoenfield, SE Schumacher… - Cancer cell, 2017 - cell.com
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly
distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3…