Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

Migraine affects over a billion individuals worldwide but its genetic underpinning remains
largely unknown. Here, we performed a genome-wide association study of 102,084 migraine …

Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers
potential advantages for locus discovery. We perform WGS in 16,324 participants from four …

Polygenic scores (PSs) are becoming a useful tool to identify individuals with high genetic risk
for complex diseases, and several projects are currently testing their utility for translational …

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic
associations into biological insights. Here, we integrate a large GWAS on blood lipids …

Background Genetic variants within nearly 1000 loci are known to contribute to modulation
of blood lipid levels. However, the biological pathways underlying these associations are …

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart
disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in …

Cardiovascular diseases are the leading cause of premature death and disability worldwide,
with both genetic and environmental determinants. While genome-wide association studies …

Multivariate methods are known to increase the statistical power to detect associations in the
case of shared genetic basis between phenotypes. They have, however, lacked essential …

Aging is a major risk factor for vascular disease. Increased levels of milk fat globule-EGF factor
8 (MFG-E8) are associated with many age-related arterial changes, but the mechanisms …