Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

… Sophie E Legge Sophie E Legge … Grace E Woolway, Sophie E Smart, Amy J Lynham,
Jennifer L Lloyd, Michael J Owen, Ian R Jones, James TR Walters, Sophie E Legge, Schizophrenia …

… g while accounting for error correlations (referred to here as the analytical SE27). All … We
evaluated the accuracy of the analytical SE for both quantitative and ascertained traits and …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

BackgroundA number of copy number variants (CNVs) have been suggested as susceptibility
factors for schizophrenia. For some of these the data remain equivocal, and the frequency …

Background Several recurrent copy number variants (CNVs) have been shown to increase
the risk of developing schizophrenia (SCZ), developmental delay (DD), autism spectrum …

Background Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease,
are calculated as a weighted count of risk alleles identified in genome-wide association …