User profiles for S. B. Rothbart
Scott B. RothbartProfessor, Van Andel Institute Verified email at vai.org Cited by 5454 |
Interpreting the language of histone and DNA modifications
SB Rothbart, BD Strahl - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …
covalent modifications to DNA and histone proteins that dependably package our genetic …
[HTML][HTML] Chromatin regulation through ubiquitin and ubiquitin-like histone modifications
Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational
modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
[PDF][PDF] Lysine methylation regulators moonlighting outside the epigenome
… We thank members of the Rothbart laboratory for their insightful discussions and critical
reading of this review. Work in the Rothbart laboratory is supported by grants from the National …
reading of this review. Work in the Rothbart laboratory is supported by grants from the National …
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
SB Rothbart, K Krajewski, N Nady, W Tempel… - Nature structural & …, 2012 - nature.com
A fundamental challenge in mammalian biology has been the elucidation of mechanisms
linking DNA methylation and histone post-translational modifications. Human UHRF1 (ubiquitin…
linking DNA methylation and histone post-translational modifications. Human UHRF1 (ubiquitin…
[PDF][PDF] An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation, and
tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. …
tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. …
Structural basis for DNMT3A-mediated de novo DNA methylation
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development 1 , 2 . Dysregulation of this …
cytosines is essential for genome regulation and development 1 , 2 . Dysregulation of this …
A DNA methylation reader complex that enhances gene transcription
DNA methylation generally functions as a repressive transcriptional signal, but it is also
known to activate gene expression. In either case, the downstream factors remain largely …
known to activate gene expression. In either case, the downstream factors remain largely …
Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation
SB Rothbart, BM Dickson, MS Ong… - Genes & …, 2013 - genesdev.cshlp.org
Histone post-translational modifications regulate chromatin structure and function largely
through interactions with effector proteins that often contain multiple histone-binding domains. …
through interactions with effector proteins that often contain multiple histone-binding domains. …
[PDF][PDF] A histone methylation network regulates transgenerational epigenetic memory in C. elegans
…, E Brookes, R Spadafora, Y Zhu, SB Rothbart… - Cell reports, 2014 - cell.com
How epigenetic information is transmitted from generation to generation remains largely
unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-…
unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-…
[PDF][PDF] An interactive database for the assessment of histone antibody specificity
Access to high-quality antibodies is a necessity for the study of histones and their posttranslational
modifications (PTMs). Here we debut the Histone Antibody Specificity Database (http://…
modifications (PTMs). Here we debut the Histone Antibody Specificity Database (http://…