User profiles for S. B. Rothbart

Scott B. Rothbart

Professor, Van Andel Institute
Verified email at vai.org
Cited by 5454

Interpreting the language of histone and DNA modifications

SB Rothbart, BD Strahl - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

[HTML][HTML] Chromatin regulation through ubiquitin and ubiquitin-like histone modifications

RM Vaughan, A Kupai, SB Rothbart - Trends in biochemical sciences, 2021 - cell.com
Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational
modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …

[PDF][PDF] Lysine methylation regulators moonlighting outside the epigenome

EM Cornett, L Ferry, PA Defossez, SB Rothbart - Molecular cell, 2019 - cell.com
… We thank members of the Rothbart laboratory for their insightful discussions and critical
reading of this review. Work in the Rothbart laboratory is supported by grants from the National …

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

SB Rothbart, K Krajewski, N Nady, W Tempel… - Nature structural & …, 2012 - nature.com
A fundamental challenge in mammalian biology has been the elucidation of mechanisms
linking DNA methylation and histone post-translational modifications. Human UHRF1 (ubiquitin…

[PDF][PDF] An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting

L Cai, SB Rothbart, R Lu, B Xu, WY Chen, A Tripathy… - Molecular cell, 2013 - cell.com
Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation, and
tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. …

Structural basis for DNMT3A-mediated de novo DNA methylation

…, Y Yu, D Chen, L Gao, S Liu, D Ji, SB Rothbart… - Nature, 2018 - nature.com
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development 1 , 2 . Dysregulation of this …

A DNA methylation reader complex that enhances gene transcription

…, M Groth, Z Wang, JA Wohlschlegel, J Du, SB Rothbart… - Science, 2018 - science.org
DNA methylation generally functions as a repressive transcriptional signal, but it is also
known to activate gene expression. In either case, the downstream factors remain largely …

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

SB Rothbart, BM Dickson, MS Ong… - Genes & …, 2013 - genesdev.cshlp.org
Histone post-translational modifications regulate chromatin structure and function largely
through interactions with effector proteins that often contain multiple histone-binding domains. …

[PDF][PDF] A histone methylation network regulates transgenerational epigenetic memory in C. elegans

…, E Brookes, R Spadafora, Y Zhu, SB Rothbart… - Cell reports, 2014 - cell.com
How epigenetic information is transmitted from generation to generation remains largely
unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-…

[PDF][PDF] An interactive database for the assessment of histone antibody specificity

SB Rothbart, BM Dickson, JR Raab, AT Grzybowski… - Molecular cell, 2015 - cell.com
Access to high-quality antibodies is a necessity for the study of histones and their posttranslational
modifications (PTMs). Here we debut the Histone Antibody Specificity Database (http://…