In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks,
most binary traits have substantially fewer cases than controls. Both of the widely used …

Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial
molecular events are unknown. Using LD score regression analysis, we show significant …

Objectives We assessed the current genetic evidence for the involvement of various cell
types and tissue types in the etiology of neurodegenerative diseases, especially in relation to …

Improvements in immunosuppression have modified short‐term survival of deceased‐donor
allografts, but not their rate of long‐term failure. Mismatches between donor and recipient …

Background Suicide claims one million lives worldwide annually, making it a serious public
health concern. The risk for suicidal behaviour can be partly explained by genetic factors, as …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

To the Editor—Advances in genotyping and sequencing technologies, the growing
availability of electronic health records for research use and the emergence of population-scale …

What makes the molecular study of psychiatric and other neurological conditions particularly
challenging compared with other complex traits is the difficulty of accessing the relevant …

With very large sample sizes, biobanks provide an exciting opportunity to identify genetic
components of complex traits. To analyze rare variants, region-based multiple-variant …

The increasing quantity and quality of functional genomic information motivate the assessment
and integration of these data with association data, including data originating from …