Activity-dependent changes in the strength of synaptic connections are fundamental to the
formation and maintenance of memory. The mechanisms underlying persistent changes in …

The axon initial segment (AIS), with its dense clusters of voltage‐gated ion channels decorating
the axonal membrane, regulates action potential initiation and modulation. The AIS also …

Maternal obesity during pregnancy has been associated with increased risk of neurodevelopmental
disorders, including autism spectrum disorder (ASD), in offspring. Here, we report …

Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum
Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) reuteri …

The core symptoms of many neurological disorders have traditionally been thought to be
caused by genetic variants affecting brain development and function. However, the gut …

At hippocampal synapses, activation of group I metabotropic glutamate receptors (mGluRs)
induces long-term depression (LTD), which requires new protein synthesis. However, the …

The maternal gut microbiome plays a critical role in fetal and early postnatal development,
shaping fundamental processes including immune maturation and brain development, among …

The axon initial segment (AIS) is the site of action potential initiation in neurons. Recent
studies have demonstrated activity-dependent regulation of the AIS, including homeostatic …

Angelman syndrome (AS) is associated with symptoms that include autism, intellectual
disability, motor abnormalities, and epilepsy. We recently showed that AS model mice have …

Rett syndrome (RTT) is a severe neurodevelopmental disorder that is usually caused by
mutations in Methyl-CpG-binding Protein 2 (MECP2). Four of the eight common disease …