MLL translocations, histone modifications and leukaemia stem-cell development

AV Krivtsov, SA Armstrong - Nature reviews cancer, 2007 - nature.com
Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA-…

[PDF][PDF] Molecular genetics of acute lymphoblastic leukemia

SA Armstrong, AT Look - Journal of Clinical Oncology, 2005 - pgcmehematology.net
From its beginnings two decades ago with the analysis of chromosomal translocation
breakpoints, research into the molecular pathogenesis of acute lymphoblastic leukemia (ALL) has …

Child‐centered play therapy in the schools: Review and meta‐analysis

DC Ray, SA Armstrong, RS Balkin… - Psychology in the …, 2015 - Wiley Online Library
The authors conducted a meta‐analysis and systematic review that examined 23 studies
evaluating the effectiveness of child centered play therapy (CCPT) conducted in elementary …

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

…, M Reich, H Hieronymus, G Wei, SA Armstrong… - science, 2006 - science.org
To pursue a systematic approach to the discovery of functional connections among diseases,
genetic perturbation, and drug action, we have created the first installment of a reference …

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

SA Armstrong, JE Staunton, LB Silverman, R Pieters… - Nature …, 2002 - nature.com
Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-lineage
leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show …

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

…, WC Hahn, DG Gilliland, TR Golub, SA Armstrong - Nature, 2006 - nature.com
Leukaemias and other cancers possess a rare population of cells capable of the limitless
self-renewal necessary for cancer initiation and maintenance 1 , 2 , 3 , 4 , 5 , 6 , 7 . Eradication …

[HTML][HTML] FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

…, S Lazo-Kallanian, IR Williams, C Sears, SA Armstrong… - Cell, 2007 - cell.com
To understand the role of FoxO family members in hematopoiesis, we conditionally deleted
FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited …

[HTML][HTML] Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

…, M Nishino, G Wei, S Korsmeyer, SA Armstrong… - Cancer cell, 2006 - cell.com
We show that the antiapoptotic proteins BCL-2, BCL-XL, MCL-1, BFL-1, and BCL-w each bear
a unique pattern of interaction with a panel of peptides derived from BH3 domains of BH3-…

High-throughput oncogene mutation profiling in human cancer

…, K Shah, H Sasaki, A Gazdar, J Minna, SA Armstrong… - Nature …, 2007 - nature.com
Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression 1 , 2 . However, widespread clinical application of this information is …

[PDF][PDF] Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor

…, KM Bernt, JC Tseng, AL Kung, SA Armstrong… - Cancer cell, 2011 - cell.com
Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis
in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …