User profiles for R. Veldhuizen

Ruud Veldhuizen

Western University
Verified email at uwo.ca
Cited by 9219

[HTML][HTML] The role of lipids in pulmonary surfactant

R Veldhuizen, K Nag, S Orgeig, F Possmayer - Biochimica et Biophysica …, 1998 - Elsevier
Pulmonary surfactant is composed of approx. 90% lipids and 10% protein. This review
article focusses on the lipid components of surfactant. The first sections will describe the lipid …

[HTML][HTML] Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation

YY Zuo, RAW Veldhuizen, AW Neumann… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10%
proteins. It plays an important role in maintaining normal respiratory mechanics by reducing …

The role of exogenous surfactant in the treatment of acute lung injury

JF Lewis, R Veldhuizen - Annual review of physiology, 2003 - annualreviews.org
▪ Abstract A number of conditions, such as pneumonia, trauma, or systemic sepsis arising
from the gut, may result in the acute respiratory distress syndrome (ARDS). Because of its …

[HTML][HTML] Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

…, T Perkmann, G van Loo, M Ermolaeva, R Veldhuizen… - Cell, 2008 - cell.com
Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high
lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4…

Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions

JL Malloy, RAW Veldhuizen… - … of Physiology-Lung …, 2005 - journals.physiology.org
Pulmonary surfactant has two distinct functions within the lung: reduction of surface tension
at the air-liquid interface and participation in innate host defense. Both functions are …

Pulmonary surfactant subfractions in patients with the acute respiratory distress syndrome.

RA Veldhuizen, LA McCaig, T Akino… - American journal of …, 1995 - atsjournals.org
Changes in the surfactant system have been observed in patients with acute respiratory
distress syndrome (ARDS). These alterations in surfactant are thought to contribute to lung …

Pulmonary surfactant: A mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing with …

Analysis of the performance of pathologists in the grading of bladder tumors

…, WAD Anderson, CL Alons, ME Boon, RW Veldhuizen - Human Pathology, 1983 - Elsevier
Fifty-seven transurethrally resected bladder tumors were analyzed to determine whether
different pathologists, using the World Health Organization grading system, graded the same …

[HTML][HTML] A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant

…, NO Petersen, F Possmayer, RAW Veldhuizen - … et Biophysica Acta (BBA …, 2012 - Elsevier
The exact mechanism by which pulmonary surfactant films reach the very low surface
tensions required to stabilize the alveoli at end expiration remains uncertain. We utilized the …

Lung lavage and surfactant replacement during ex vivo lung perfusion for treatment of gastric acid aspiration–induced donor lung injury

…, JF Lewis, M Post, RAW Veldhuizen… - The Journal of Heart and …, 2017 - Elsevier
Background Ex vivo lung perfusion (EVLP) provides opportunities to treat injured donor
lungs before transplantation. We investigated whether lung lavage, to eliminate inflammatory …