Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

We present single-molecule, real-time sequencing data obtained from a DNA polymerase
performing uninterrupted template-directed synthesis using four distinguishable fluorescently …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

DNA sequencing has revolutionized medicine over recent decades. However, analysis of
large structural variation and repetitive DNA, a hallmark of human genomes, has been limited …

Background A large outbreak of diarrhea and the hemolytic–uremic syndrome caused by an
unusual serotype of Shiga-toxin–producing Escherichia coli (O104:H4) began in Germany …

… Activation of A 1 R suppresses D1 neuron responses in the striatum both by limiting … R-mediated
inhibition of protein kinase A (PKA) activity 33,34 . In support of the idea that ADO–A 1 R …

… /R orientation rather than the expected outward-facing R/F orientation). Reads were then
mapped to the hg19 reference genome using ‘bwa mem’ 6 with default settings, and duplicates …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical
syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe …

We present the first comprehensive analysis of a diploid human genome that combines
single-molecule sequencing with single-molecule genome maps. Our hybrid assembly markedly …

Background Centromeres are essential for chromosome segregation, yet their DNA sequences
evolve rapidly. In most animals and plants that have been studied, centromeres contain …