Interpreting the effects of genetic variants is key to understanding individual susceptibility to
disease and designing personalized therapeutic approaches. Modern experimental …

To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone,
and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to …

… Regions of higher complexity are weakly associated with more highly expressed genes (r
2 = 0.19), indicating that low-complexity binding sites are associated with more restricted …

Background Limited clinical and laboratory data are available on patients with Ebola virus
disease (EVD). The Kenema Government Hospital in Sierra Leone, which had an existing …

The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented
magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of …

We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …

The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …

The 2013–2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little
is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause …

Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering
dissection of COVID-19 biology. We use comparative genomics to provide a high-confidence …