User profiles for R. Schlapbach

Ralph Schlapbach

Functional Genomics Center Zurich
Verified email at fgcz.uzh.ch
Cited by 9121

Oxidants in mitochondria: from physiology to diseases

…, V Gogvadze, R Laffranchi, R Schlapbach… - … et Biophysica Acta (BBA …, 1995 - Elsevier
Reactive oxygen species (ROS: superoxide radical, O 2 − ; hydrogen peroxide, H 2 O 2 ;
hydroxyl radical, OH), which arise from the univalent reduction of dioxygen are formed in …

PhosphoPep—a phosphoproteome resource for systems biology research in Drosophila Kc167 cells

…, HK Lee, R Schlapbach, R Aebersold - Molecular systems …, 2007 - embopress.org
The ability to analyze and understand the mechanisms by which cells process information is
a key question of systems biology research. Such mechanisms critically depend on …

Community proteogenomics reveals insights into the physiology of phyllosphere bacteria

…, B Roschitzki, R Schlapbach… - Proceedings of the …, 2009 - National Acad Sciences
Aerial plant surfaces represent the largest biological interface on Earth and provide
essential services as sites of carbon dioxide fixation, molecular oxygen release, and primary …

[HTML][HTML] Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

…, MP Molloy, RL Moritz, S Ohtsuki, R Schlapbach… - Nature …, 2017 - nature.com
… site was computed and the R 2 values averaged 0.97 (R 2 values for individual peptides are
… fmol), and removal of that point increased the R 2 to 0.99. Since this study was performed, a …

Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast

…, B Roschitzki, C Zhang, KM Shokat, R Schlapbach… - Science …, 2010 - science.org
The phosphorylation and dephosphorylation of proteins by kinases and phosphatases
constitute an essential regulatory network in eukaryotic cells. This network supports the flow of …

[HTML][HTML] DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro

…, B Timmermann, N Selevsek, R Schlapbach… - Scientific reports, 2019 - nature.com
… Thereafter, the read counts for each gene were used for determination of differentially
expressed genes using the DESeq2 63 R package (v.1.16.1). Here, the design was set according …

A high-quality catalog of the Drosophila melanogaster proteome

…, AJR Heck, E Hafen, R Schlapbach, R Aebersold - Nature …, 2007 - nature.com
Understanding how proteins and their complex interaction networks convert the genomic
information into a dynamic living organism is a fundamental challenge in biological sciences. …

[HTML][HTML] Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori

…, B Linz, R Ghai, KP Pleissner, R Schlapbach… - PLoS …, 2005 - journals.plos.org
… These matrices were used to calculate Neighbor-joining phylogenetic trees whose branch
order was compared by Pearson correlation coefficients (r). The phylogenetic trees differed …

[HTML][HTML] Qualitative and Quantitative Analyses of Protein Phosphorylation in Naive and Stimulated Mouse Synaptosomal Preparations* S

…, B Gerrits, C Panse, R Schlapbach… - Molecular & Cellular …, 2007 - ASBMB
Activity-dependent protein phosphorylation is a highly dynamic yet tightly regulated process
essential for cellular signaling. Although recognized as critical for neuronal functions, the …

PhosphoPep—a database of protein phosphorylation sites in model organisms

…, P Picotti, R Schlapbach, R Aebersold - Nature …, 2008 - nature.com
Reversible protein phosphorylation is a universal process that is involved in the control of
most biological processes. The comprehensive and quantitative analysis of the protein …