Physical detection of antigen-specific CD4 T cells has revealed features of the in vivo
immune response that were not appreciated from in vitro studies. In vivo, antigen is initially …

… Using a cell blot technique Manhart & Reinhardt (unpublished data) have shown a
significantly increased proportion of IL-4 secreting cells extracted from rapidly progressive …

Allergic disease represents a significant global health burden, and disease incidence continues
to rise in urban areas of the world. As such, a better understanding of the basic immune …

We report here that cells co-purifying with mesenchymal stem cells—termed here multipotent
adult progenitor cells or MAPCs—differentiate, at the single cell level, not only into …

We have sequenced and annotated the genome of fission yeast (Schizosaccharomycespombe),
which contains the smallest number of protein-coding genes yet recorded for a …

Leishmania species cause a spectrum of human diseases in tropical and subtropical regions
of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid …

Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes
Down syndrome, the most frequent genetic cause of significant mental retardation, which …

… Statistical analyses were performed using a series of packages and scripts developed in R.
Significant … We are grateful to R. Panstruga and P. Bakker for comments on the manuscript. …

Type 2 immunity is a stereotyped host response to allergens and parasitic helminths that is
sustained in large part by the cytokines IL-4 and IL-13. Recent advances have called …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens 1 , 2 , 3 , 4 , differentiate into memory cells that produce anti-microbial …