We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Abnormal intracellular protein aggregates comprise a key characteristic in most neurodegenerative
diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …

Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. Until recently, the underlying cause was known in only a minority of cases that were …

Several families have been reported with autosomal-dominant frontotemporal dementia (FTD)
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …

Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …

Frontotemporal dementia (FTD) is the second most common cause of dementia in people
under the age of 65 years 1 . A large proportion of FTD patients (35–50%) have a family history …

Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions (both
cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 region (…

Algorithms designed to identify canonical yeast prions predict that around 250 human
proteins, including several RNA-binding proteins associated with neurodegenerative disease, …

To identify novel causes of familial neurodegenerative diseases, we extended our previous
studies of TAR DNA‐binding protein 43 (TDP‐43) proteinopathies to investigate TDP‐43 as …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating
neurodegenerative disorders with clinical, genetic, and neuropathological overlap. …