User profiles for R. Pomès

Régis Pomès

Hospital for Sick Children
Verified email at sickkids.ca
Cited by 5269

Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery

L Huynh, C Neale, R Pomès, C Allen - … : nanotechnology, biology and …, 2012 - Elsevier
… , R g = R/√6, where R is the root-mean-squared end-to-end distance of the polymer. Here,
R … that R ≈ aN α , where α is the swelling exponent (Eq 4, Table 1).55, 79 In a good solvent, …

Role of liquid–liquid phase separation in assembly of elastin and other extracellular matrix proteins

LD Muiznieks, S Sharpe, R Pomès… - Journal of molecular …, 2018 - Elsevier
Liquid–liquid phase separation resulting in formation of colloidal droplets has recently
attracted attention as a mechanism for rapid and transient assembly of intracellular …

[HTML][HTML] Sampling errors in free energy simulations of small molecules in lipid bilayers

C Neale, R Pomès - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
… the Lennard-Jones cutoff radius r c = 0.9 nm and forms a defect involving invagination of
only one leaflet when r c ≥ 1.0 nm, presumably because as r c decreases the bilayer becomes …

[HTML][HTML] Molecular mechanism of H+ conduction in the single-file water chain of the gramicidin channel

R Pomes, B Roux - Biophysical journal, 2002 - cell.com
The conduction of protons in the hydrogen-bonded chain of water molecules (or "proton wire")
embedded in the lumen of gramicidin A is studied with molecular dynamics free energy …

[HTML][HTML] Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

…, D Pichugin, N Tsuchimura, ST Larda, R Pomès… - Nature …, 2018 - nature.com
Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their
mechanisms are poorly understood. Here, 19 F NMR is used to delineate the effects of cations …

The role of dimer asymmetry and protomer dynamics in enzyme catalysis

…, Z Ren, A Sljoka, C Ing, A Bezginov, L Ye, R Pomès… - Science, 2017 - science.org
INTRODUCTION Enzymes greatly accelerate biochemical reactions by providing a scaffold
to bind and recognize substrate, position catalytic units, and facilitate the formation of …

Statistical convergence of equilibrium properties in simulations of molecular solutes embedded in lipid bilayers

…, WFD Bennett, DP Tieleman, R Pomes - Journal of Chemical …, 2011 - ACS Publications
… COM and each headgroup phosphorus atom, r P , were measured with the GROMACS … for
some figures, was computed only for lipids with r P ≤ 1 nm. Order parameters were computed …

[HTML][HTML] Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export

…, Y Ah Kim, R Collins, W Trimble, R Pomès… - Nature …, 2019 - nature.com
The intracellular transport of cholesterol is subject to tight regulation. The structure of the
lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large …

The liquid structure of elastin

S Rauscher, R Pomès - Elife, 2017 - elifesciences.org
… Copyright Rauscher and Pome` s. This article is distributed under the terms of the Creative
Commons … Rauscher and R. Pome`s, ‘Microsecond-long molecular dynamics trajectory of an …

[PDF][PDF] Molecular basis of proton blockage in aquaporins

N Chakrabarti, E Tajkhorshid, B Roux, R Pomès - Structure, 2004 - cell.com
… in water chains confined in nonpolar environments (Pome` s Protons versus Other Ions …
time-scale commensurate with proton permeation (Yu and Pome`s, tween a cation and Arg206 is …