User profiles for R. Pomès
Régis PomèsHospital for Sick Children Verified email at sickkids.ca Cited by 5269 |
Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery
… , R g = R/√6, where R is the root-mean-squared end-to-end distance of the polymer. Here,
R … that R ≈ aN α , where α is the swelling exponent (Eq 4, Table 1).55, 79 In a good solvent, …
R … that R ≈ aN α , where α is the swelling exponent (Eq 4, Table 1).55, 79 In a good solvent, …
Role of liquid–liquid phase separation in assembly of elastin and other extracellular matrix proteins
LD Muiznieks, S Sharpe, R Pomès… - Journal of molecular …, 2018 - Elsevier
Liquid–liquid phase separation resulting in formation of colloidal droplets has recently
attracted attention as a mechanism for rapid and transient assembly of intracellular …
attracted attention as a mechanism for rapid and transient assembly of intracellular …
[HTML][HTML] Sampling errors in free energy simulations of small molecules in lipid bilayers
C Neale, R Pomès - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
… the Lennard-Jones cutoff radius r c = 0.9 nm and forms a defect involving invagination of
only one leaflet when r c ≥ 1.0 nm, presumably because as r c decreases the bilayer becomes …
only one leaflet when r c ≥ 1.0 nm, presumably because as r c decreases the bilayer becomes …
[HTML][HTML] Molecular mechanism of H+ conduction in the single-file water chain of the gramicidin channel
The conduction of protons in the hydrogen-bonded chain of water molecules (or "proton wire")
embedded in the lumen of gramicidin A is studied with molecular dynamics free energy …
embedded in the lumen of gramicidin A is studied with molecular dynamics free energy …
[HTML][HTML] Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
…, D Pichugin, N Tsuchimura, ST Larda, R Pomès… - Nature …, 2018 - nature.com
Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their
mechanisms are poorly understood. Here, 19 F NMR is used to delineate the effects of cations …
mechanisms are poorly understood. Here, 19 F NMR is used to delineate the effects of cations …
The role of dimer asymmetry and protomer dynamics in enzyme catalysis
INTRODUCTION Enzymes greatly accelerate biochemical reactions by providing a scaffold
to bind and recognize substrate, position catalytic units, and facilitate the formation of …
to bind and recognize substrate, position catalytic units, and facilitate the formation of …
Statistical convergence of equilibrium properties in simulations of molecular solutes embedded in lipid bilayers
… COM and each headgroup phosphorus atom, r P , were measured with the GROMACS … for
some figures, was computed only for lipids with r P ≤ 1 nm. Order parameters were computed …
some figures, was computed only for lipids with r P ≤ 1 nm. Order parameters were computed …
[HTML][HTML] Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export
…, Y Ah Kim, R Collins, W Trimble, R Pomès… - Nature …, 2019 - nature.com
The intracellular transport of cholesterol is subject to tight regulation. The structure of the
lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large …
lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large …
The liquid structure of elastin
S Rauscher, R Pomès - Elife, 2017 - elifesciences.org
… Copyright Rauscher and Pome` s. This article is distributed under the terms of the Creative
Commons … Rauscher and R. Pome`s, ‘Microsecond-long molecular dynamics trajectory of an …
Commons … Rauscher and R. Pome`s, ‘Microsecond-long molecular dynamics trajectory of an …
[PDF][PDF] Molecular basis of proton blockage in aquaporins
… in water chains confined in nonpolar environments (Pome` s Protons versus Other Ions …
time-scale commensurate with proton permeation (Yu and Pome`s, tween a cation and Arg206 is …
time-scale commensurate with proton permeation (Yu and Pome`s, tween a cation and Arg206 is …