Astrocytes locally translate transcripts in their peripheral processes
…, AM Lake, R Khazanchi, R Ouwenga… - Proceedings of the …, 2017 - National Acad Sciences
Local translation in neuronal processes is key to the alteration of synaptic strength necessary
for long-term potentiation, learning, and memory. Here, we present evidence that regulated …
for long-term potentiation, learning, and memory. Here, we present evidence that regulated …
[PDF][PDF] MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts
Directed reprogramming of human fibroblasts into fully differentiated neurons requires massive
changes in epigenetic and transcriptional states. Induction of a chromatin environment …
changes in epigenetic and transcriptional states. Induction of a chromatin environment …
[PDF][PDF] A population-based study of autosomal-recessive disease-causing mutations in a founder population
JX Chong, R Ouwenga, RL Anderson… - The American Journal of …, 2012 - cell.com
… R 1 with the reference haplotype until it reaches a SNP for which IBS ¼ 0. The same procedure
is used for scanning SNPs on the other side of the mutation, and the total length of IBS R …
is used for scanning SNPs on the other side of the mutation, and the total length of IBS R …
Transcriptomic analysis of ribosome-bound mRNA in cortical neurites in vivo
Localized translation in neurites helps regulate synaptic strength and development. Dysregulation
of local translation is associated with many neurological disorders. However, due to …
of local translation is associated with many neurological disorders. However, due to …
Mammary tumors induce select cognitive impairments
LM Pyter, SF Cochrane, RL Ouwenga, PN Patel… - Brain, behavior, and …, 2010 - Elsevier
Cancer, in addition to many other chronic diseases, is associated with serious and problematic
behavioral symptoms, including cognitive impairments. In humans, various factors likely …
behavioral symptoms, including cognitive impairments. In humans, various factors likely …
[HTML][HTML] Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders
RL Ouwenga, J Dougherty - Molecular autism, 2015 - Springer
… random genes with the same distribution of expression as the 716 Fmrp genes surviving the
filters above, we computed a kernel density estimate on the logCPM (function ‘density’ in R) …
filters above, we computed a kernel density estimate on the logCPM (function ‘density’ in R) …
The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms
Local translation in neurites is a phenomenon that enhances the spatial segregation of proteins
and their functions away from the cell body, yet it is unclear how local translation varies …
and their functions away from the cell body, yet it is unclear how local translation varies …
Disclosure of genetic research results to members of a founder population
RL Anderson, K Murray, JX Chong, R Ouwenga… - Journal of genetic …, 2014 - Springer
There is currently extensive discussion and debate in the literature on how, when, and to
whom genetic research results should be returned (see Genetics in Medicine, April 2012 issue)…
whom genetic research results should be returned (see Genetics in Medicine, April 2012 issue)…
Development Potentials for Superchargers
M Lau, DR Ouwenga - ATZautotechnology, 2011 - Springer
Since 1989 the Eaton Roots type supercharger is being used on many engine applications
because of its immediate transient time-to-torque behaviour and reliability. Coming from …
because of its immediate transient time-to-torque behaviour and reliability. Coming from …
Development Potentials for Superchargers
M Lau, DR Ouwenga - Auto Tech Review, 2012 - Springer
Since 1989 the Eaton Roots type supercharger is being used on many engine applications
because of its immediate transient time-to-torque behaviour and reliability. Coming from …
because of its immediate transient time-to-torque behaviour and reliability. Coming from …