Increasing multidrug resistance in Gram-negative bacteria, in particular Pseudomonas
aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, presents a critical problem. …

Infections caused by multi-resistant Gram-negative bacteria, particularly Pseudomonas
aeruginosa, are increasing worldwide. In patients with cystic fibrosis (CF), resistance in P. …

In this review, we outline the rationale for targeting blood pressure and blood cholesterol
lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their …

… associate professor of clinical epidemiology1, Paul P Glasziou director and professor of
evidence based medicine1, Isabelle Boutron professor of epidemiology2, Ruairidh Milne …

Background Data for front-line health-care workers and risk of COVID-19 are limited. We
sought to assess risk of COVID-19 among front-line health-care workers compared with the …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …

Background In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut
mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

Epidemiological, pathological and genetic studies show a strong positive correlation between
elevated plasma concentrations of low-density lipoprotein (LDL) cholesterol and the risk of …