Many developments have occurred since the publication of the widely-used 2009 Canadian
Cardiovascular Society (CCS) Dyslipidemia guidelines. Here, we present an updated …

… Jacques Genest MD1, Ruth McPherson MD PhD2, Jiri Frohlich MD3, Todd Anderson MD4,
Norm Campbell MD4, André Carpentier MD5, Patrick Couture MD6, Robert Dufour MD7 …

Since the publication of the 2012 guidelines new literature has emerged to inform decision-making.
The 2016 guidelines primary panel selected a number of clinically relevant …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

… as those on the McPherson study (Ottawa, … , McPherson’s group used custom oligonucleotide
arrays to assay 100,000 SNPs. Helgadottir et al also used SNP technology. As McPherson …

For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods
has been recognized as the premier text in clinical laboratory medicine, widely used by …

Heritable variation in complex traits is generally considered to be conferred by common
DNA sequence polymorphisms. We tested whether rare DNA sequence variants collectively …