Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

… in the R package lmerTest (63). The R 2 for the LMMs was assessed using the R MuMIn …
For their robustness, we used generalized estimating equations as implemented in the R …

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

The Illumina 450k array is a frequently used platform for large-scale genome-wide DNA
methylation studies, ie epigenome-wide association studies. Currently, quality control of 450k …

Combustion experiments of an activated carbon (Norit RX Extra), catalyzed by CuCl2, were
conducted in triplicate in a flow of moist air containing 5 vol% HC1 at 300 C to reveal the …

We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …

… Quality control (QC) on the DNA methylation data was performed using the R package …
[30], we used the implementation in the R package minfi [64] to impute the cell fractions of …

Severe myoclonic epilepsy of infancy (SMEI) or Dravet syndrome is a rare epilepsy syndrome.
In 30 to 70% of SMEI patients, truncating and missense mutations in the neuronal voltage‐…

Subtelomeric rearrangements are responsible for 5% to 10% of cases of unexplained mental
retardation. Despite their clinical relevance, methods to screen for these cytogenetically …