An understanding of the mechanisms underlying body-weight regulation is crucial to tackle
the growing problem of obesity. Recent technological advances in the analysis of genetic …

Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human
cancers and chronic inflammatory lesions. In mouse models of cancer, they have been …

More than one-half billion people are obese, and despite progress in genetic research,
much of the heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent …

The strongest BMI–associated GWAS locus in humans is the FTO gene. Rodent studies
demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes …

The gut endocrine system is emerging as a central player in the control of appetite and
glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of …

It is widely accepted that moving from a linear to circular economy for plastics will be
beneficial to reduce plastic pollution in our environment and to prevent loss of material value. …

The epidermal growth factor (EGF) superfamily comprises a diverse group of proteins that
function as secreted signaling molecules, growth factors, and components of the extracellular …

… Histogram of body weight 10 weeks after surgery was generated in R using the easyGgplot2
package. Differential gene expression was calculated using the glm functionality in EdgeR. …

An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are
among those most strongly and reproducibly associated with obesity. The gene closest to …

The hypothalamus, pituitary, and gonads coordinate to direct the development and regulation
of reproductive function in mammals. Control of the hypothalamic–pituitary–gonadal axis is …