[HTML][HTML] Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study
Aims/hypothesis Metformin use has been associated with reduced incidence of dementia in
diabetic individuals in observational studies. However, the causality between the two in the …
diabetic individuals in observational studies. However, the causality between the two in the …
Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study
…, J Zheng, R Korologou-Linden… - International journal …, 2020 - academic.oup.com
… F statistics provide an indication of instrument strength 22 and are a function of R 2 (how
much variance in the trait is explained by the set of genetic instruments being used), the number …
much variance in the trait is explained by the set of genetic instruments being used), the number …
[HTML][HTML] Causal effects of circulating cytokine concentrations on risk of Alzheimer's disease and cognitive function
… one were not publicly available, we used summary estimates from Korologou- Linden et
al. (… in the outcome GWAS, we searched for proxy variants using the LDLink online tool (r 2 …
al. (… in the outcome GWAS, we searched for proxy variants using the LDLink online tool (r 2 …
Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis
…, B Brumpton, R Korologou-Linden… - International journal …, 2021 - academic.oup.com
Background It is established that Alzheimer’s disease (AD) patients experience sleep
disruption. However, it remains unknown whether disruption in the quantity, quality or timing of …
disruption. However, it remains unknown whether disruption in the quantity, quality or timing of …
[PDF][PDF] Smoking, DNA methylation, and lung function: a mendelian randomization analysis to investigate causal pathways
E Jamieson, R Korologou-Linden, RE Wootton… - The American Journal of …, 2020 - cell.com
Whether smoking-associated DNA methylation has a causal effect on lung function has not
been thoroughly evaluated. We first investigated the causal effects of 474 smoking-…
been thoroughly evaluated. We first investigated the causal effects of 474 smoking-…
Multi-omics analyses of cognitive traits and psychiatric disorders highlight brain-dependent mechanisms
R Korologou-Linden, GM Leyden… - Human molecular …, 2023 - academic.oup.com
… We did this by applying the R package ‘dist’ to compare the distances between our MR
estimates for the same gene across the eight cognitive traits and psychiatric disorders. These …
estimates for the same gene across the eight cognitive traits and psychiatric disorders. These …
[HTML][HTML] High sustained virological response rates using imported generic direct acting antiviral treatment for hepatitis C
…, V Houghton-Price, R Korologou-Linden… - Journal of virus …, 2017 - Elsevier
Background High prices of direct acting antivirals (DAAs) for hepatitis C virus (HCV) can lead
to restrictions on access to treatment in high- and middle-income countries. An increasing …
to restrictions on access to treatment in high- and middle-income countries. An increasing …
InterPrEP: internet‐based pre‐exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London–analysis of pharmacokinetics, safety and …
X Wang, N Nwokolo, R Korologou‐Linden, A Hill… - HIV …, 2018 - Wiley Online Library
Objectives The National Health Service in England (NHS England) does not provide pre‐exposure
prophylaxis (PrEP) against HIV, forcing people to purchase generic versions on the …
prophylaxis (PrEP) against HIV, forcing people to purchase generic versions on the …
[HTML][HTML] The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization
R Korologou-Linden, L Bhatta, BM Brumpton… - Nature …, 2022 - nature.com
… The APOE region explains a large proportion of the variance in the polygenic risk score (R
2 … The GWAS on the blood-based biomarkers was performed by Roxanna Korologou-Linden, …
2 … The GWAS on the blood-based biomarkers was performed by Roxanna Korologou-Linden, …
Safety and efficacy of parenteral iron in children with inflammatory bowel disease
…, D Patel, R Korologou‐Linden… - British Journal of …, 2018 - Wiley Online Library
Aims Iron deficiency anaemia frequently complicates inflammatory bowel disease (IBD) in
children and adults. Oral iron may exacerbate gastrointestinal symptoms and absorption may …
children and adults. Oral iron may exacerbate gastrointestinal symptoms and absorption may …