User profiles for R. Kopan
 | Raphael KopanCincinnati Children's Hospital Medical Center Verified email at cchmc.org Cited by 38460 |
[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan - Cell, 2009 - cell.com
… In the absence of NICD, CSL may associate with ubiquitous corepressor (Co-R) proteins
and histone deacetylases (HDACs) to repress transcription of some target genes. Upon NICD …
and histone deacetylases (HDACs) to repress transcription of some target genes. Upon NICD …
[HTML][HTML] Notch signaling: from the outside in
Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …
NOTCH AND PRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration
▪ Abstract Intensive studies of three proteins—Presenilin, Notch, and the amyloid precursor
protein (APP)—have led to the recognition of a direct intersection between early development …
protein (APP)—have led to the recognition of a direct intersection between early development …
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions
during development, requires ligand-induced cleavage of Notch. This cleavage occurs …
during development, requires ligand-induced cleavage of Notch. This cleavage occurs …
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
EH Schroeter, JA Kisslinger, R Kopan - Nature, 1998 - nature.com
… Ornitz and members of the Kopan lab for reading and commenting on the … Raphael Kopan
… & Kopan, R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular …
… & Kopan, R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular …
Signalling downstream of activated mammalian Notch
NOTCH belongs to a family of transmembrane proteins that are widely conserved from flies
to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the …
to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the …
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
Innate lymphoid cells (ILCs) of the ILC22 type protect the intestinal mucosa from infection by
secreting interleukin 22 (IL-22). ILC22 cells include NKp46 + and lymphoid tissue–inducer (…
secreting interleukin 22 (IL-22). ILC22 cells include NKp46 + and lymphoid tissue–inducer (…
[PDF][PDF] A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
… Consis- 1 or S1) after the recognition sequence RQRR (Kopan tent with this observation, we
… members of the Kopan lab for insightful discussions during the (Chen and Okayama, 1987). …
… members of the Kopan lab for insightful discussions during the (Chen and Okayama, 1987). …
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of
Parkinson's disease. LRRK2 is a large protein containing a small GTPase domain and a …
Parkinson's disease. LRRK2 is a large protein containing a small GTPase domain and a …
[PDF][PDF] Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
F Costantini, R Kopan - Developmental cell, 2010 - cell.com
The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of a …
different developmental histories. The collecting system arises by the reiterated branching of a …