Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells …

It is widely accepted that complex interactions between cancer cells and their surrounding
microenvironment contribute to disease development, chemo-resistance and disease relapse. …

Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal
hematopoiesis-related somatic mutations and the development of myeloid malignancies, such as …

Bone marrow contains numerous different cell types arising from hematopoietic stem cells (HSCs)
and non-hematopoietic mesenchymal/skeletal stem cells, in addition to other cell …

… Inset to each graph shows Pearson’s correlation coefficient r and significance value. … The
limma BioConductor R package was used to perform analyses of gene differential expression, …

Measuring three-dimensional (3D) localization of hematopoietic stem cells (HSCs) within the
bone marrow microenvironment using intravital microscopy is a rapidly expanding research …

… controlling the high-level parameter transformation, we select the values of p min and R
which maximize the model evidence p(v 1:T ), evaluated by summing the (un-normalized) …

… fitnesses (captured by the fitness ratio ρ = r / p ⁠), we have only assumed that a migrating
HSC will not seek out other deteriorated niches with fitness r ⁠, and not move away again from …

Background: In cardiac surgery, myocardial protection is required during cross-clamping
followed by reperfusion. The use of cardioplegic solutions helps preserve myocardial energy …

Different MPNs have distinct rates of malignant transformation (PMF>PV>ET). Although PV
and ET can arise from hematopoietic stem/progenitor cells (HSPCs) with similarly activated …