Here we conducted a large-scale genetic association analysis of educational attainment in
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior
and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Several studies have suggested an association between antisocial, aggressive, and
delinquent behavior and the short variant of the serotonin transporter gene polymorphism (5‐…

… We calculated this expected R 2 from the GWAS summary … R 2 of a PGI derived from a joint
analysis of the candidate and supplementary phenotype summary statistics. If the expected R …

… The few missing values were imputed using the k-nearest neighboring (KNN) imputation
algorithm implemented in the R Bioconductor package impute 43 . Age acceleration (AA) was …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …

… R 2 ) for predicting EA (or test scores in ALSPAC ARIES). The incremental R 2 is the difference
in R 2 … PGS, and the incremental R 2 was calculated as the difference in R 2 relative to the …

… To estimate the marginal R 2 of TBV on fluid intelligence and educational attainment, we
computed the change in R 2 between a model that includes all covariates (including genetic …