Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

…, U Liebel, C Cetin, F Sieckmann, G Pau, R Kabbe… - Nature, 2010 - nature.com
Despite our rapidly growing knowledge about the human genome, we do not know all of the
genes required for some of the most basic functions of life. To start to fill this gap we …

[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma

…, C von Kalle, V Ast, C Lawerenz, J Eils, R Kabbe… - Nature, 2012 - nature.com
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …

[PDF][PDF] Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

…, R Eils, C Gerhäuser, PH Huang, B Hutter, R Kabbe… - Cancer cell, 2013 - cell.com
… TMA Statistical Analysis Logistic regression analyses were performed using the generalized
linear model glm package in R. Statistical significance and fitness of the models were …

[HTML][HTML] A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

…, R Drews, N Paramasivam, R Kabbe… - Nature …, 2015 - nature.com
… Lines are fitted against the Michaelis–Menten model using the ‘drc’ package in R. Solid lines
are fitted to the data points and dashed lines are simulated using a mixed inhibition model …

[HTML][HTML] Genomic footprints of activated telomere maintenance mechanisms in cancer

…, I Cortés-Ciriano, R Xi, R Kabbe, PJ Park, R Eils… - Nature …, 2020 - nature.com
… However, this age effect only has a low contribution to the strong correlation between the
telomere content of the tumor and control samples (r = 0.47 and r partial = 0.46 given the …

Large-scale uniform analysis of cancer whole genomes in multiple computing environments

…, S Imoto, S Ivkovic, SH Jeon, W Jiao, J Jung, R Kabbe… - BioRxiv, 2017 - biorxiv.org
The International Cancer Genome Consortium (ICGC)’s Pan-Cancer Analysis of Whole
Genomes (PCAWG) project aimed to categorize somatic and germline variations in both coding …

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

…, LE Heisler, J Hinton, N Jäger, D Jones, R Kabbe… - Biorxiv, 2014 - biorxiv.org
… Lines are fitted against the Michaelis-Menten model using the ‘drc’ package in R. Solid lines
are fitted to the data points and dashed lines are simulated using a mixed inhibition model …

[HTML][HTML] Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

…, I Cortés-Ciriano, R Xi, R Kabbe, PJ Park, R Eils… - nature …, 2022 - nature.com
In the published version of this paper, the members of the Pan-Cancer Analysis of Whole
Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these …

A comprehensive assessment of somatic mutation calling in cancer genomes

…, P Hennings-Yeomans, B Hutter, N Jäger, R Kabbe… - bioRxiv, 2014 - biorxiv.org
R has a concentration of called mutations on chromosomes 11, 13, 14, 15 and 21. The full
… Correspondence analysis was performed using the ‘ca’ package in R on a table where each …

Synthesis and reactions of 4‐chromanones

HJ Kabbe, A Widdig - Angewandte Chemie International …, 1982 - Wiley Online Library
… Further experiments with unsaturated aldehydes and ketones of type 33 aimed at introduction
of only the R'-C-R2 moiety into the chromanone met without success; either no definite …