CLINICAL SCENARIO A 55-year-old man had his serum cholesterol level measured at a
shopping mall 2 months ago. His cholesterol level was elevated and he comes to you, his …

Intrinsic (innate) and acquired (adaptive) resistance to chemotherapy critically limits the
outcome of cancer treatments. For many years, it was assumed that the interaction of a drug with …

Objective: To assess internists' familiarity with, confidence in, and attitudes about practice
guidelines issued by various organizations. Design: Cross-sectional, self-administered survey. …

Background The effects of intensive glucose control on cardiovascular events in patients with
long-standing type 2 diabetes mellitus remain uncertain. Methods We randomly assigned …

''N a recent paper'on the question of parity in weak ~-interactions, Lee and Yang critically
surveyed the experimental information concerning this question and reached the conclusion …

CLINICAL SCENARIO You are back where we put you in the previous article 1 on diagnostic
tests in this series on how to use the medical literature: in the library studying an article that …

Background The Veterans Affairs Diabetes Trial previously showed that intensive glucose
lowering, as compared with standard therapy, did not significantly reduce the rate of major …

CLINICAL SCENARIO You are working as an internal medicine resident in a rheumatology
rotation and are seeing a 19-year-old woman who has had systemic lupus erythematosus …

Background Cutaneous squamous-cell carcinomas and keratoacanthomas are common
findings in patients treated with BRAF inhibitors. Methods We performed a molecular analysis to …

THE ULTIMATE PURPOSE of applied health research is to improve health care. Summarizing
the literature to adduce recommendations for clinical practice is an important part of the …