Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this specificity …

… The change in vessel resistance is proportional to the length (L) of the vessel and the viscosity
(η) of the blood and inversely proportional to the radius of the vessel to the fourth power (r …

… For example, enzyme HincII will cut DNA sites that match the consensus GTYRAC (R = Ade
or Gua), but the affinity for all other DNA sites is orders of lower magnitude (46). However, …

Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries
with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining …

DNA sequence is a major determinant of the binding specificity of transcription factors (TFs)
for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with …

… finding were TFs with low-quality data (R 2 < 0.25) and, to a … observed even larger
improvements in R 2 when DNA shape … of lower quality (in terms of R 2 ) for some members of …

… The resulting raw data for each slide were loess-normalized using the LIMMA package in
R. … The Pearson correlation between replicate 1 and replicate 2 was R = 0.71. Additional …

… A line drawn on the WT cortex in (P) indicates ventricular length and was superimposed
on transgenic cortices in (Q) and (R). Note no evidence of cortical gyrification was seen. (S) …

Sequencing of exomes and genomes has revealed abundant genetic variation affecting the
coding sequences of human transcription factors (TFs), but the consequences of such …

Background Transcription factors (TFs) play a central role in regulating gene expression by
interacting with cis-regulatory DNA elements associated with their target genes. Recent …