R: a language for data analysis and graphics

R Ihaka, R Gentleman - Journal of computational and graphical …, 1996 - Taylor & Francis
In this article we discuss our experience designing and implementing a statistical computing
language. In developing this new language, we sought to combine what we felt were useful …

[HTML][HTML] Software for computing and annotating genomic ranges

…, P Aboyoun, M Carlson, R Gentleman… - PLoS computational …, 2013 - journals.plos.org
… We introduce a DataFrame class that behaves similarly to the base R data.frame, but supports
storage of complex vector-like objects (eg, a DNAStringSet, representing DNA sequences, …

Orchestrating high-throughput genomic analysis with Bioconductor

W Huber, VJ Carey, R Gentleman, S Anders… - Nature …, 2015 - nature.com
… We have embraced R for its scientific and statistical computing capabilities, for its … R's foreign
language interfaces can be exploited to access an established software library from within R

Open source software for the analysis of microarray data

S Dudoit, RC Gentleman, J Quackenbush - Biotechniques, 2003 - Future Science
… Here we review three of the most widely used and comprehensive systems, the statistical
analysis tools written in R through the Bioconductor project ( http://www.bioconductor.org ), the …

Circulating microRNAs as stable blood-based markers for cancer detection

…, DL Stirewalt, R Gentleman… - Proceedings of the …, 2008 - National Acad Sciences
Improved approaches for the detection of common epithelial malignancies are urgently
needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) …

[HTML][HTML] Bioconductor: open software development for computational biology and bioinformatics

RC Gentleman, VJ Carey, DM Bates, B Bolstad… - Genome biology, 2004 - Springer
… with R suggested that its range of well-implemented statistical and visualization tools would
decrease development and distribution time for robust software for CBB. We also note that R

[HTML][HTML] Graphs in molecular biology

W Huber, VJ Carey, L Long, S Falcon, R Gentleman - BMC bioinformatics, 2007 - Springer
… For concreteness, we will show the R programming code to perform this analysis. Figures 3,
… includes all the R code for analysis and graphics displays. It is available as additional file 1. …

A model-based background adjustment for oligonucleotide expression arrays

Z Wu, RA Irizarry, R Gentleman… - Journal of the …, 2004 - Taylor & Francis
High-density oligonucleotide expression arrays are widely used in many areas of biomedical
research. Affymetrix GeneChip arrays are the most popular. In the Affymetrix system, a fair …

Using GOstats to test gene lists for GO term association

S Falcon, R Gentleman - Bioinformatics, 2007 - academic.oup.com
… Results: We discuss the capabilities of GOstats, a Bioconductor package written in R, that
allows users to test GO terms for over or under-representation using either a classical …

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

…, J Stinson, F Gnad, PM Haverty, R Gentleman… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis.
Here, we obtained exome, transcriptome and copy-number alteration data from …