R: a language for data analysis and graphics
R Ihaka, R Gentleman - Journal of computational and graphical …, 1996 - Taylor & Francis
In this article we discuss our experience designing and implementing a statistical computing
language. In developing this new language, we sought to combine what we felt were useful …
language. In developing this new language, we sought to combine what we felt were useful …
[HTML][HTML] Software for computing and annotating genomic ranges
…, P Aboyoun, M Carlson, R Gentleman… - PLoS computational …, 2013 - journals.plos.org
… We introduce a DataFrame class that behaves similarly to the base R data.frame, but supports
storage of complex vector-like objects (eg, a DNAStringSet, representing DNA sequences, …
storage of complex vector-like objects (eg, a DNAStringSet, representing DNA sequences, …
Orchestrating high-throughput genomic analysis with Bioconductor
… We have embraced R for its scientific and statistical computing capabilities, for its … R's foreign
language interfaces can be exploited to access an established software library from within R…
language interfaces can be exploited to access an established software library from within R…
Open source software for the analysis of microarray data
S Dudoit, RC Gentleman, J Quackenbush - Biotechniques, 2003 - Future Science
… Here we review three of the most widely used and comprehensive systems, the statistical
analysis tools written in R through the Bioconductor project ( http://www.bioconductor.org ), the …
analysis tools written in R through the Bioconductor project ( http://www.bioconductor.org ), the …
Circulating microRNAs as stable blood-based markers for cancer detection
…, DL Stirewalt, R Gentleman… - Proceedings of the …, 2008 - National Acad Sciences
Improved approaches for the detection of common epithelial malignancies are urgently
needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) …
needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) …
[HTML][HTML] Bioconductor: open software development for computational biology and bioinformatics
RC Gentleman, VJ Carey, DM Bates, B Bolstad… - Genome biology, 2004 - Springer
… with R suggested that its range of well-implemented statistical and visualization tools would
decrease development and distribution time for robust software for CBB. We also note that R …
decrease development and distribution time for robust software for CBB. We also note that R …
[HTML][HTML] Graphs in molecular biology
W Huber, VJ Carey, L Long, S Falcon, R Gentleman - BMC bioinformatics, 2007 - Springer
… For concreteness, we will show the R programming code to perform this analysis. Figures 3,
… includes all the R code for analysis and graphics displays. It is available as additional file 1. …
… includes all the R code for analysis and graphics displays. It is available as additional file 1. …
A model-based background adjustment for oligonucleotide expression arrays
Z Wu, RA Irizarry, R Gentleman… - Journal of the …, 2004 - Taylor & Francis
High-density oligonucleotide expression arrays are widely used in many areas of biomedical
research. Affymetrix GeneChip arrays are the most popular. In the Affymetrix system, a fair …
research. Affymetrix GeneChip arrays are the most popular. In the Affymetrix system, a fair …
Using GOstats to test gene lists for GO term association
S Falcon, R Gentleman - Bioinformatics, 2007 - academic.oup.com
… Results: We discuss the capabilities of GOstats, a Bioconductor package written in R, that
allows users to test GO terms for over or under-representation using either a classical …
allows users to test GO terms for over or under-representation using either a classical …
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
…, J Stinson, F Gnad, PM Haverty, R Gentleman… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis.
Here, we obtained exome, transcriptome and copy-number alteration data from …
Here, we obtained exome, transcriptome and copy-number alteration data from …