User profiles for R. Danev
Radostin DanevThe University of Tokyo Verified email at biochem.mpg.de Cited by 8328 |
Cryo-electron microscopy methodology: current aspects and future directions
Cryo-electron microscopy (cryo-EM) has emerged as a powerful structure determination
technique. Its most prolific branch is single particle analysis (SPA), a method being used in a …
technique. Its most prolific branch is single particle analysis (SPA), a method being used in a …
Expanding the boundaries of cryo-EM with phase plates
R Danev, W Baumeister - Current opinion in structural biology, 2017 - Elsevier
… Radostin Danev is a co-inventor with no financial benefits in US patent US9129774 B2 ‘Method
of using a phase plate in a transmission electron microscope’. Wolfgang Baumeister is …
of using a phase plate in a transmission electron microscope’. Wolfgang Baumeister is …
Visualizing the molecular sociology at the HeLa cell nuclear periphery
The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here
we combined recent developments in cryo–electron tomography (cryo-ET) to produce three-…
we combined recent developments in cryo–electron tomography (cryo-ET) to produce three-…
Volta potential phase plate for in-focus phase contrast transmission electron microscopy
R Danev, B Buijsse, M Khoshouei… - Proceedings of the …, 2014 - National Acad Sciences
We describe a phase plate for transmission electron microscopy taking advantage of a
hitherto-unknown phenomenon, namely a beam-induced Volta potential on the surface of a …
hitherto-unknown phenomenon, namely a beam-induced Volta potential on the surface of a …
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …
Phase contrast electron microscopy: development of thin-film phase plates and biological applications
K Nagayama, R Danev - Philosophical Transactions of …, 2008 - royalsocietypublishing.org
Phase contrast transmission electron microscopy (TEM) based on thin-film phase plates has
been developed and applied to biological systems. Currently, development is focused on …
been developed and applied to biological systems. Currently, development is focused on …
Transmission electron microscopy with Zernike phase plate
R Danev, K Nagayama - Ultramicroscopy, 2001 - Elsevier
… The spatial frequency k h is related to the hole radius r h through the formula:(3) k h = r h fλ
, where f is the focal length of the objective. Effects such as charging or contamination could …
, where f is the focal length of the objective. Effects such as charging or contamination could …
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
… Further comparison of our active A 1 R structure with either of the A 2A R active or … sites
between agonist-bound A 1 R and A 2A R, suggesting that the propagation and selection of …
between agonist-bound A 1 R and A 2A R, suggesting that the propagation and selection of …
A molecular census of 26S proteasomes in intact neurons
The 26S proteasome is a key player in eukaryotic protein quality control and in the regulation
of numerous cellular processes. Here, we describe quantitative in situ structural studies of …
of numerous cellular processes. Here, we describe quantitative in situ structural studies of …
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
… We also report the structure of the A 1 R co-bound to adenosine, MIPS521 and a G i2
heterotrimer, revealing an extrahelical lipid–detergent-facing allosteric binding pocket that involves …
heterotrimer, revealing an extrahelical lipid–detergent-facing allosteric binding pocket that involves …