Climie et al Macrovasculature and Microvasculature in HTN and T2D 1139 million global
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension rarely …

Prevention of cardiovascular disease (CVD) remains one of the largest public health challenges
of our time. Identifying individuals at increased cardiovascular risk at an asymptomatic, …

Context/purpose Observational and acute laboratory intervention research has shown that
excessive sedentary time is associated adversely with cardiometabolic biomarkers. This …

The genetic circuits that allow cancer cells to evade destruction by the host immune system
remain poorly understood 1 , 2 – 3 . Here, to identify a phenotypically robust core set of …

The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the
study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) …

Fibers remain undigested until they reach the colon, where some are fermented by gut
microbiota, producing metabolites called short-chain fatty acids (SCFAs), such as acetate and …

… *RE Climie and MJ Wheeler are co-first authors of this work. … *RE Climie and MJ Wheeler
are co-first authors of this work. … * RE Climie and MJ Wheeler are co-first authors of this work. …

… Rachel ED Climie … There was a significant correlation between the O CBP - and T CBP
-determined augmentation index measured in all three positions (r = 0.684, P < 0.001). …

In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts
mitigates impairment in vascular function. However, it is unknown whether these benefits extend …

… and haemodynamics of the vascular beds in various territories (eg brain, kidney, retina and
sublingua) can be assessed via imaging techniques that have been reviewed by Climie et al. …