We previously identified missense mutations in the U2AF1 splicing factor affecting codons
S34 (S34F and S34Y) or Q157 (Q157R and Q157P) in 11% of the patients with de novo …

We have asked how the common S34F mutation in the splicing factor U2AF1 regulates
alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this …

How the essential pre-mRNA splicing factor U2AF 65 recognizes the polypyrimidine (Py)
signals of the major class of 3′ splice sites in human gene transcripts remains incompletely …

… The observed correlations are in good agreement between the two datasets (Pearson r = …
Pearson R test was used to determine the correlation coefficients between splicing modules …

The 3′ UTR (UTR) of human mRNAs plays a critical role in controlling protein expression
and function. Importantly, 3′ UTRs of human messages are not invariant for each gene but …

Dysregulated pre-mRNA splicing is an emerging Achilles heel of cancers and myelodysplasias.
To expand the currently limited portfolio of small-molecule drug leads, we screened for …

RNA binding proteins (RBPs) frequently regulate the expression of other RBPs in mammalian
cells. Such cross-regulation has been proposed to be important to control networks of …

Splicing factor 1 (SF1) recognizes 3′ splice sites of the major class of introns as a ternary
complex with U2AF 65 and U2AF 35 splicing factors. A conserved SPSP motif in a coiled-coil …

… recognition of 3’ splice sites includes a pyrimidine at the -3 position (yAG|r) [19], it was …
cassette (by genomic PCR using the P1-F and P1-R primers as described in … where X is …

Recognition of the 3 splice site is a crucial step in pre-mRNA splicing, which is accomplished
by a dynamic complex comprising splicing factor 1 (SF1) and the U2 auxiliary factor …